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IP6K2

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GENERAL INFORMATION

Gene name

 IP6K2

Gene description

 Inositol hexakisphosphate kinase 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 21
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus & intermediate filaments.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved), Intermediate filaments (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA007532
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus & intermediate filaments.

Main location

 Nucleus (approved), Intermediate filaments (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA007532 U-2 OS No staining    
HPA007532 U-251 MG Nucleus
Intermediate filaments

GENE INFORMATION

Gene name

 IP6K2 (HGNC Symbol)

Synonyms

 IHPK2

Description

 Inositol hexakisphosphate kinase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 48688003 - 48740353

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000068745 (version 83.38)

Entrez gene

 51447

UniProt

 Q9UHH9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHH9

Antibodypedia

 IP6K2 antibodies

PROTEIN BROWSER
«
IP6K2-001
IP6K2-002
IP6K2-003
IP6K2-006
IP6K2-007
IP6K2-010
IP6K2-011
IP6K2-012
IP6K2-013
IP6K2-014
IP6K2-015
IP6K2-016
IP6K2-017
IP6K2-018
IP6K2-020
IP6K2-021
IP6K2-023
IP6K2-024
IP6K2-025
IP6K2-026
IP6K2-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IP6K2-001
ENSP00000331103
ENST00000328631
Q9UHH9 [Direct mapping]
Inositol hexakisphosphate kinase 2
B2RCP4 [Target identity:100%; Query identity:100%]
Inositol hexaphosphate kinase 2, isoform CRA_e; cDNA FLJ13983 fis, clone Y79AA1001827, highly similar to Inositol hexakisphosphate kinase 2 (EC 2.7.4.21); cDNA, FLJ96192, highly similar to Homo sapiens inositol hexaphosphate kinase 2 (IHPK2), mRNA
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Show all
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006817 [phosphate ion transport]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0043065 [positive regulation of apoptotic process]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0052723 [inositol hexakisphosphate 1-kinase activity]
GO:0052724 [inositol hexakisphosphate 3-kinase activity]
GO:0060337 [type I interferon signaling pathway]
Show all
 426 aa
49.2 kDa 		No 0
IP6K2-002
ENSP00000341925
ENST00000340879
Q9UHH9 [Direct mapping]
Inositol hexakisphosphate kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Show all
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0043065 [positive regulation of apoptotic process]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0052723 [inositol hexakisphosphate 1-kinase activity]
GO:0052724 [inositol hexakisphosphate 3-kinase activity]
GO:0060337 [type I interferon signaling pathway]
Show all
 97 aa
11.2 kDa 		No 0
IP6K2-003
ENSP00000414139
ENST00000431721
Q9UHH9 [Direct mapping]
Inositol hexakisphosphate kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Show all
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0043065 [positive regulation of apoptotic process]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0052723 [inositol hexakisphosphate 1-kinase activity]
GO:0052724 [inositol hexakisphosphate 3-kinase activity]
GO:0060337 [type I interferon signaling pathway]
Show all
 185 aa
20.9 kDa 		No 0
IP6K2-006
ENSP00000393077
ENST00000449610
C9JHV2 [Direct mapping]
Inositol hexakisphosphate kinase 2
Show all
Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0016310 [phosphorylation]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 130 aa
14.8 kDa 		No 0
IP6K2-007
ENSP00000399052
ENST00000446860
Q9UHH9 [Direct mapping]
Inositol hexakisphosphate kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Show all
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0043065 [positive regulation of apoptotic process]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0052723 [inositol hexakisphosphate 1-kinase activity]
GO:0052724 [inositol hexakisphosphate 3-kinase activity]
GO:0060337 [type I interferon signaling pathway]
Show all
 188 aa
21.3 kDa 		No 0
IP6K2-010
ENSP00000411776
ENST00000449563
C9J536 [Direct mapping]
Inositol hexakisphosphate kinase 2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0016310 [phosphorylation]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 130 aa
14.7 kDa 		No 0
IP6K2-011
ENSP00000414428
ENST00000413654
C9JLG7 [Direct mapping]
Inositol hexakisphosphate kinase 2
Show all
Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0016310 [phosphorylation]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 104 aa
11.8 kDa 		No 0
IP6K2-012
ENSP00000389761
ENST00000443853
C9JMC9 [Direct mapping]
Inositol hexakisphosphate kinase 2
Show all
Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0016310 [phosphorylation]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 100 aa
11.4 kDa 		No 0
IP6K2-013
ENSP00000403968
ENST00000437427
C9JHX0 [Direct mapping]
Inositol hexakisphosphate kinase 2
Show all
Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0016310 [phosphorylation]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 91 aa
10.5 kDa 		No 0
IP6K2-014
ENSP00000395819
ENST00000412850
C9JGK2 [Direct mapping]
Inositol hexakisphosphate kinase 2
Show all
Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0016310 [phosphorylation]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 87 aa
10.1 kDa 		No 0
IP6K2-015
ENSP00000412121
ENST00000454335
C9J124 [Direct mapping]
Inositol hexakisphosphate kinase 2
Show all
Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0016310 [phosphorylation]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 140 aa
16 kDa 		No 0
IP6K2-016
ENSP00000396203
ENST00000413298
Q9UHH9 [Direct mapping]
Inositol hexakisphosphate kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Show all
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0043065 [positive regulation of apoptotic process]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0052723 [inositol hexakisphosphate 1-kinase activity]
GO:0052724 [inositol hexakisphosphate 3-kinase activity]
GO:0060337 [type I interferon signaling pathway]
Show all
 97 aa
11.2 kDa 		No 0
IP6K2-017
ENSP00000394488
ENST00000450045
C9JRM0 [Direct mapping]
Inositol hexakisphosphate kinase 2
Show all
Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0016310 [phosphorylation]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 151 aa
17.2 kDa 		No 0
IP6K2-018
ENSP00000410454
ENST00000455545
C9J3W9 [Direct mapping]
Inositol hexakisphosphate kinase 2
Show all
Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0016310 [phosphorylation]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 148 aa
17 kDa 		No 0
IP6K2-020
ENSP00000388116
ENST00000417896
C9JHV2 [Direct mapping]
Inositol hexakisphosphate kinase 2
Show all
Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0016310 [phosphorylation]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 130 aa
14.8 kDa 		No 0
IP6K2-021
ENSP00000410950
ENST00000443964
C9J8W6 [Direct mapping]
Inositol hexakisphosphate kinase 2
Show all
Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0016310 [phosphorylation]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 189 aa
21.4 kDa 		No 0
IP6K2-023
ENSP00000387394
ENST00000453202
C9JHV2 [Direct mapping]
Inositol hexakisphosphate kinase 2
Show all
Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0016310 [phosphorylation]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 130 aa
14.8 kDa 		No 0
IP6K2-024
ENSP00000393797
ENST00000440424
C9JU99 [Direct mapping]
Inositol hexakisphosphate kinase 2
Show all
Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0016310 [phosphorylation]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 55 aa
6.3 kDa 		No 0
IP6K2-025
ENSP00000388420
ENST00000434860
A0A0E3D6M0 [Direct mapping]
Inositol hexakisphosphate kinase 2
Show all
Predicted intracellular proteins
Show all
 54 aa
6.2 kDa 		No 0
IP6K2-026
ENSP00000406357
ENST00000424035
C9J790 [Direct mapping]
Inositol hexakisphosphate kinase 2
Show all
Predicted intracellular proteins
Show all
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0016310 [phosphorylation]
Show all
 95 aa
10.6 kDa 		No 0
IP6K2-201
ENSP00000400812
ENST00000432678
Q9UHH9 [Direct mapping]
Inositol hexakisphosphate kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Show all
GO:0000832 [inositol hexakisphosphate 5-kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0043065 [positive regulation of apoptotic process]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0052723 [inositol hexakisphosphate 1-kinase activity]
GO:0052724 [inositol hexakisphosphate 3-kinase activity]
GO:0060337 [type I interferon signaling pathway]
Show all
 87 aa
9.8 kDa 		No 0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.