Fields »
ABOUT
HELP
BLOG
PITX1

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 PITX1

Gene description

 Paired-like homeodomain 1

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoli.

RNA cell category

 Cell line enhanced (T-47d, CACO-2, K-562)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA008743
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (T-47d, CACO-2, K-562)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoli.

Main location

 Nucleoli (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA008743 A-431 Nucleoli Intensity
HPA008743 U-2 OS Nucleoli

GENE INFORMATION

Gene name

 PITX1 (HGNC Symbol)

Synonyms

 BFT, POTX, PTX1

Description

 Paired-like homeodomain 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q31.1

Chromosome location (bp)

 135027735 - 135034813

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000069011 (version 83.38)

Entrez gene

 5307

UniProt

 P78337 (UniProt - Evidence at protein level)

neXtProt

 NX_P78337

Antibodypedia

 PITX1 antibodies

PROTEIN BROWSER
PITX1-001
PITX1-002
PITX1-003
PITX1-004
PITX1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PITX1-001
ENSP00000265340
ENST00000265340
P78337 [Direct mapping]
Pituitary homeobox 1
X5D9A5 [Target identity:100%; Query identity:100%]
Paired-like homeodomain 1 isoform A
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding]
GO:0001501 [skeletal system development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0009653 [anatomical structure morphogenesis]
GO:0014707 [branchiomeric skeletal muscle development]
GO:0021983 [pituitary gland development]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0035137 [hindlimb morphogenesis]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048625 [myoblast fate commitment]
GO:0051216 [cartilage development]
Show all
 314 aa
34.1 kDa 		No 0
PITX1-002
ENSP00000427542
ENST00000506438
P78337 [Direct mapping]
Pituitary homeobox 1
X5D9A5 [Target identity:100%; Query identity:100%]
Paired-like homeodomain 1 isoform A
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0009653 [anatomical structure morphogenesis]
GO:0043565 [sequence-specific DNA binding]
Show all
 314 aa
34.1 kDa 		No 0
PITX1-003
ENSP00000423624
ENST00000502676
D6R955 [Direct mapping]
Pituitary homeobox 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
Show all
 114 aa
12.4 kDa 		No 0
PITX1-004
ENSP00000422908
ENST00000507253
D6R9U1 [Direct mapping]
Pituitary homeobox 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
Show all
 131 aa
14.4 kDa 		No 0
PITX1-005
ENSP00000451199
ENST00000503586
H0YJC8 [Direct mapping]
Pituitary homeobox 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 208 aa
23 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.