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Most colorectal cancers, a majority of ovarian and cervical cancers along with few lung, urothelial and prostate cancers showed moderate nuclear membranous positivity. Remaining cancers were in general weakly stained or negative.
GENE INFORMATION
Gene name
NUP133 (HGNC Symbol)
Synonyms
FLJ10814
Description
Nucleoporin 133kDa (HGNC Symbol)
Entrez gene summary
The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008]
Q8WUM0 [Direct mapping] Nuclear pore complex protein Nup133
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Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
