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Weak to moderate nuclear immunoreactivity was observed in few urothelial-, breast- and cervical cancers and lymphomas. Most other cancer tissues were negative.
GENE INFORMATION
Gene name
BCL3 (HGNC Symbol)
Synonyms
BCL4, D19S37
Description
B-cell CLL/lymphoma 3 (HGNC Symbol)
Entrez gene summary
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
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GO:0000060 [protein import into nucleus, translocation] GO:0002268 [follicular dendritic cell differentiation] GO:0002315 [marginal zone B cell differentiation] GO:0002455 [humoral immune response mediated by circulating immunoglobulin] GO:0002467 [germinal center formation] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006974 [cellular response to DNA damage stimulus] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0008134 [transcription factor binding] GO:0009615 [response to virus] GO:0010225 [response to UV-C] GO:0019730 [antimicrobial humoral response] GO:0030198 [extracellular matrix organization] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0030674 [protein binding, bridging] GO:0032729 [positive regulation of interferon-gamma production] GO:0032996 [Bcl3-Bcl10 complex] GO:0033257 [Bcl3/NF-kappaB2 complex] GO:0042088 [T-helper 1 type immune response] GO:0042345 [regulation of NF-kappaB import into nucleus] GO:0042536 [negative regulation of tumor necrosis factor biosynthetic process] GO:0042742 [defense response to bacterium] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042832 [defense response to protozoan] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0045064 [T-helper 2 cell differentiation] GO:0045082 [positive regulation of interleukin-10 biosynthetic process] GO:0045171 [intercellular bridge] GO:0045415 [negative regulation of interleukin-8 biosynthetic process] GO:0045727 [positive regulation of translation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048471 [perinuclear region of cytoplasm] GO:0048536 [spleen development] GO:0051101 [regulation of DNA binding] GO:0051457 [maintenance of protein location in nucleus]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
