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Most malignant cells showed weak to moderate cytoplasmic staining. Cases of malignant gliomas, one cervical squamous cell carcinoma and basal cell carcinoma exhibited strong positivity. Malignant carcinoids, colorectal and gastric cancers were generally negative.
Most malignant cells displayed weak to moderate cytoplasmic immunoreactivity. Strong staining was observed in several cases of breast, prostate and colorectal cancer.
Most cancer tissues showed weak to moderate cytoplasmic and nuclear staining. Few cases of pancreas and renal cancers displayed additional membranous positivity. Lymphoma were negative.
Transporters Accessory Factors Involved in Transport MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000151 [ubiquitin ligase complex] GO:0000785 [chromatin] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006622 [protein targeting to lysosome] GO:0007041 [lysosomal transport] GO:0010766 [negative regulation of sodium ion transport] GO:0010768 [negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016327 [apicolateral plasma membrane] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0019089 [transmission of virus] GO:0019221 [cytokine-mediated signaling pathway] GO:0019871 [sodium channel inhibitor activity] GO:0019904 [protein domain specific binding] GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031175 [neuron projection development] GO:0031623 [receptor internalization] GO:0031698 [beta-2 adrenergic receptor binding] GO:0032801 [receptor catabolic process] GO:0034644 [cellular response to UV] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042921 [glucocorticoid receptor signaling pathway] GO:0043130 [ubiquitin binding] GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway] GO:0044111 [development involved in symbiotic interaction] GO:0045732 [positive regulation of protein catabolic process] GO:0046824 [positive regulation of nucleocytoplasmic transport] GO:0048471 [perinuclear region of cytoplasm] GO:0048814 [regulation of dendrite morphogenesis] GO:0050815 [phosphoserine binding] GO:0050816 [phosphothreonine binding] GO:0050847 [progesterone receptor signaling pathway] GO:0051592 [response to calcium ion] GO:0061630 [ubiquitin protein ligase activity] GO:0070062 [extracellular exosome] GO:0070063 [RNA polymerase binding] GO:0070064 [proline-rich region binding] GO:0070534 [protein K63-linked ubiquitination] GO:1901016 [regulation of potassium ion transmembrane transporter activity] GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
Transporters Accessory Factors Involved in Transport MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000151 [ubiquitin ligase complex] GO:0000785 [chromatin] GO:0002250 [adaptive immune response] GO:0003151 [outflow tract morphogenesis] GO:0003197 [endocardial cushion development] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005902 [microvillus] GO:0005938 [cell cortex] GO:0006513 [protein monoubiquitination] GO:0006622 [protein targeting to lysosome] GO:0006955 [immune response] GO:0007041 [lysosomal transport] GO:0007528 [neuromuscular junction development] GO:0008022 [protein C-terminus binding] GO:0010766 [negative regulation of sodium ion transport] GO:0010768 [negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014894 [response to denervation involved in regulation of muscle adaptation] GO:0016020 [membrane] GO:0016327 [apicolateral plasma membrane] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0019089 [transmission of virus] GO:0019221 [cytokine-mediated signaling pathway] GO:0019871 [sodium channel inhibitor activity] GO:0019904 [protein domain specific binding] GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031175 [neuron projection development] GO:0031623 [receptor internalization] GO:0031698 [beta-2 adrenergic receptor binding] GO:0032801 [receptor catabolic process] GO:0034644 [cellular response to UV] GO:0034765 [regulation of ion transmembrane transport] GO:0042110 [T cell activation] GO:0042391 [regulation of membrane potential] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042921 [glucocorticoid receptor signaling pathway] GO:0043130 [ubiquitin binding] GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway] GO:0044111 [development involved in symbiotic interaction] GO:0045121 [membrane raft] GO:0045732 [positive regulation of protein catabolic process] GO:0046824 [positive regulation of nucleocytoplasmic transport] GO:0048471 [perinuclear region of cytoplasm] GO:0048514 [blood vessel morphogenesis] GO:0048814 [regulation of dendrite morphogenesis] GO:0050807 [regulation of synapse organization] GO:0050815 [phosphoserine binding] GO:0050816 [phosphothreonine binding] GO:0050847 [progesterone receptor signaling pathway] GO:0051592 [response to calcium ion] GO:0061630 [ubiquitin protein ligase activity] GO:0070062 [extracellular exosome] GO:0070063 [RNA polymerase binding] GO:0070064 [proline-rich region binding] GO:0070534 [protein K63-linked ubiquitination] GO:1901016 [regulation of potassium ion transmembrane transporter activity] GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
Transporters Accessory Factors Involved in Transport MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex] GO:0000785 [chromatin] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006622 [protein targeting to lysosome] GO:0007041 [lysosomal transport] GO:0010766 [negative regulation of sodium ion transport] GO:0010768 [negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016327 [apicolateral plasma membrane] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0019089 [transmission of virus] GO:0019221 [cytokine-mediated signaling pathway] GO:0019871 [sodium channel inhibitor activity] GO:0019904 [protein domain specific binding] GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031175 [neuron projection development] GO:0031623 [receptor internalization] GO:0031698 [beta-2 adrenergic receptor binding] GO:0032801 [receptor catabolic process] GO:0034644 [cellular response to UV] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042921 [glucocorticoid receptor signaling pathway] GO:0043130 [ubiquitin binding] GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway] GO:0044111 [development involved in symbiotic interaction] GO:0045732 [positive regulation of protein catabolic process] GO:0046824 [positive regulation of nucleocytoplasmic transport] GO:0048471 [perinuclear region of cytoplasm] GO:0048814 [regulation of dendrite morphogenesis] GO:0050815 [phosphoserine binding] GO:0050816 [phosphothreonine binding] GO:0050847 [progesterone receptor signaling pathway] GO:0051592 [response to calcium ion] GO:0061630 [ubiquitin protein ligase activity] GO:0070062 [extracellular exosome] GO:0070063 [RNA polymerase binding] GO:0070064 [proline-rich region binding] GO:0070534 [protein K63-linked ubiquitination] GO:1901016 [regulation of potassium ion transmembrane transporter activity] GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
Transporters Accessory Factors Involved in Transport MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex] GO:0000785 [chromatin] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006622 [protein targeting to lysosome] GO:0007041 [lysosomal transport] GO:0010766 [negative regulation of sodium ion transport] GO:0010768 [negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016327 [apicolateral plasma membrane] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0019089 [transmission of virus] GO:0019221 [cytokine-mediated signaling pathway] GO:0019871 [sodium channel inhibitor activity] GO:0019904 [protein domain specific binding] GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031175 [neuron projection development] GO:0031623 [receptor internalization] GO:0031698 [beta-2 adrenergic receptor binding] GO:0032801 [receptor catabolic process] GO:0034644 [cellular response to UV] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042921 [glucocorticoid receptor signaling pathway] GO:0043130 [ubiquitin binding] GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway] GO:0044111 [development involved in symbiotic interaction] GO:0045732 [positive regulation of protein catabolic process] GO:0046824 [positive regulation of nucleocytoplasmic transport] GO:0048471 [perinuclear region of cytoplasm] GO:0048814 [regulation of dendrite morphogenesis] GO:0050815 [phosphoserine binding] GO:0050816 [phosphothreonine binding] GO:0050847 [progesterone receptor signaling pathway] GO:0051592 [response to calcium ion] GO:0061630 [ubiquitin protein ligase activity] GO:0070062 [extracellular exosome] GO:0070063 [RNA polymerase binding] GO:0070064 [proline-rich region binding] GO:0070534 [protein K63-linked ubiquitination] GO:1901016 [regulation of potassium ion transmembrane transporter activity] GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]