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RAB27A

GENERAL INFORMATION

Gene name

 RAB27A

Gene description

 RAB27A, member RAS oncogene family

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues, including immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA001333 , CAB034046
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RAB27A (HGNC Symbol)

Synonyms

 GS2, HsT18676, RAB27, RAM

Description

 RAB27A, member RAS oncogene family (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q21.3

Chromosome location (bp)

 55202966 - 55319113

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000069974 (version 83.38)

Entrez gene

 5873

UniProt

 P51159 (UniProt - Evidence at protein level)

neXtProt

 NX_P51159

Antibodypedia

 RAB27A antibodies

PROTEIN BROWSER
RAB27A-001
RAB27A-002
RAB27A-003
RAB27A-004
RAB27A-005
RAB27A-006
RAB27A-009
RAB27A-010
RAB27A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAB27A-001
ENSP00000379601
ENST00000396307
P51159 [Direct mapping]
Ras-related protein Rab-27A
A2RU94 [Target identity:100%; Query identity:100%]
RAB27A, member RAS oncogene family; RAB27A, member RAS oncogene family, isoform CRA_a; cDNA, FLJ93274, Homo sapiens RAB27A, member RAS oncogene family (RAB27A), mRNA
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001750 [photoreceptor outer segment]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005794 [Golgi apparatus]
GO:0006605 [protein targeting]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0009306 [protein secretion]
GO:0010628 [positive regulation of gene expression]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0016324 [apical plasma membrane]
GO:0019003 [GDP binding]
GO:0019882 [antigen processing and presentation]
GO:0019904 [protein domain specific binding]
GO:0030141 [secretory granule]
GO:0030318 [melanocyte differentiation]
GO:0030425 [dendrite]
GO:0030667 [secretory granule membrane]
GO:0031489 [myosin V binding]
GO:0032400 [melanosome localization]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
GO:0032585 [multivesicular body membrane]
GO:0033093 [Weibel-Palade body]
GO:0036257 [multivesicular body organization]
GO:0042470 [melanosome]
GO:0043316 [cytotoxic T cell degranulation]
GO:0043320 [natural killer cell degranulation]
GO:0043473 [pigmentation]
GO:0044267 [cellular protein metabolic process]
GO:0045921 [positive regulation of exocytosis]
GO:0048489 [synaptic vesicle transport]
GO:0050766 [positive regulation of phagocytosis]
GO:0051875 [pigment granule localization]
GO:0051904 [pigment granule transport]
GO:0070062 [extracellular exosome]
GO:0070382 [exocytic vesicle]
GO:0071985 [multivesicular body sorting pathway]
GO:0097278 [complement-dependent cytotoxicity]
GO:1903307 [positive regulation of regulated secretory pathway]
GO:1903428 [positive regulation of reactive oxygen species biosynthetic process]
GO:1903435 [positive regulation of constitutive secretory pathway]
GO:1990182 [exosomal secretion]
Show all
 221 aa
24.9 kDa 		No 0
RAB27A-002
ENSP00000455012
ENST00000564609
P51159 [Direct mapping]
Ras-related protein Rab-27A
A2RU94 [Target identity:100%; Query identity:100%]
RAB27A, member RAS oncogene family; RAB27A, member RAS oncogene family, isoform CRA_a; cDNA, FLJ93274, Homo sapiens RAB27A, member RAS oncogene family (RAB27A), mRNA
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0009306 [protein secretion]
GO:0010628 [positive regulation of gene expression]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0019882 [antigen processing and presentation]
GO:0030141 [secretory granule]
GO:0030425 [dendrite]
GO:0032400 [melanosome localization]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
GO:0032585 [multivesicular body membrane]
GO:0036257 [multivesicular body organization]
GO:0042470 [melanosome]
GO:0044267 [cellular protein metabolic process]
GO:0045921 [positive regulation of exocytosis]
GO:0048489 [synaptic vesicle transport]
GO:0050766 [positive regulation of phagocytosis]
GO:0070062 [extracellular exosome]
GO:0070382 [exocytic vesicle]
GO:0071985 [multivesicular body sorting pathway]
GO:0097278 [complement-dependent cytotoxicity]
GO:1903307 [positive regulation of regulated secretory pathway]
GO:1903428 [positive regulation of reactive oxygen species biosynthetic process]
GO:1903435 [positive regulation of constitutive secretory pathway]
GO:1990182 [exosomal secretion]
Show all
 221 aa
24.9 kDa 		No 0
RAB27A-003
ENSP00000456059
ENST00000569493
P51159 [Direct mapping]
Ras-related protein Rab-27A
A2RU94 [Target identity:100%; Query identity:100%]
RAB27A, member RAS oncogene family; RAB27A, member RAS oncogene family, isoform CRA_a; cDNA, FLJ93274, Homo sapiens RAB27A, member RAS oncogene family (RAB27A), mRNA
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0009306 [protein secretion]
GO:0010628 [positive regulation of gene expression]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0019882 [antigen processing and presentation]
GO:0030141 [secretory granule]
GO:0030425 [dendrite]
GO:0032400 [melanosome localization]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
GO:0032585 [multivesicular body membrane]
GO:0036257 [multivesicular body organization]
GO:0042470 [melanosome]
GO:0044267 [cellular protein metabolic process]
GO:0045921 [positive regulation of exocytosis]
GO:0048489 [synaptic vesicle transport]
GO:0050766 [positive regulation of phagocytosis]
GO:0070062 [extracellular exosome]
GO:0070382 [exocytic vesicle]
GO:0071985 [multivesicular body sorting pathway]
GO:0097278 [complement-dependent cytotoxicity]
GO:1903307 [positive regulation of regulated secretory pathway]
GO:1903428 [positive regulation of reactive oxygen species biosynthetic process]
GO:1903435 [positive regulation of constitutive secretory pathway]
GO:1990182 [exosomal secretion]
Show all
 221 aa
24.9 kDa 		No 0
RAB27A-004
ENSP00000456536
ENST00000565972
H3BS49 [Direct mapping]
Ras-related protein Rab-27A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0009306 [protein secretion]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030141 [secretory granule]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
Show all
 136 aa
15.5 kDa 		No 0
RAB27A-005
ENSP00000457517
ENST00000568803
H3BU81 [Direct mapping]
Ras-related protein Rab-27A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0006886 [intracellular protein transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0007264 [small GTPase mediated signal transduction]
GO:0009306 [protein secretion]
GO:0030141 [secretory granule]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
Show all
 71 aa
7.9 kDa 		No 0
RAB27A-006
ENSP00000454695
ENST00000566877
H3BN55 [Direct mapping]
Ras-related protein Rab-27A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0009306 [protein secretion]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030141 [secretory granule]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
Show all
 185 aa
21 kDa 		No 0
RAB27A-009
ENSP00000457595
ENST00000563262
H3BUD9 [Direct mapping]
Ras-related protein Rab-27A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0006886 [intracellular protein transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0007264 [small GTPase mediated signal transduction]
GO:0009306 [protein secretion]
GO:0015031 [protein transport]
GO:0030141 [secretory granule]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
Show all
 95 aa
10.7 kDa 		No 0
RAB27A-010
ENSP00000458127
ENST00000567380
H3BVH7 [Direct mapping]
Ras-related protein Rab-27A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0009306 [protein secretion]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030141 [secretory granule]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
Show all
 146 aa
16.7 kDa 		No 0
RAB27A-201
ENSP00000337761
ENST00000336787
P51159 [Direct mapping]
Ras-related protein Rab-27A
A2RU94 [Target identity:100%; Query identity:100%]
RAB27A, member RAS oncogene family; RAB27A, member RAS oncogene family, isoform CRA_a; cDNA, FLJ93274, Homo sapiens RAB27A, member RAS oncogene family (RAB27A), mRNA
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0009306 [protein secretion]
GO:0010628 [positive regulation of gene expression]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0019882 [antigen processing and presentation]
GO:0030141 [secretory granule]
GO:0030425 [dendrite]
GO:0032400 [melanosome localization]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
GO:0032585 [multivesicular body membrane]
GO:0036257 [multivesicular body organization]
GO:0042470 [melanosome]
GO:0044267 [cellular protein metabolic process]
GO:0045921 [positive regulation of exocytosis]
GO:0048489 [synaptic vesicle transport]
GO:0050766 [positive regulation of phagocytosis]
GO:0070062 [extracellular exosome]
GO:0070382 [exocytic vesicle]
GO:0071985 [multivesicular body sorting pathway]
GO:0097278 [complement-dependent cytotoxicity]
GO:1903307 [positive regulation of regulated secretory pathway]
GO:1903428 [positive regulation of reactive oxygen species biosynthetic process]
GO:1903435 [positive regulation of constitutive secretory pathway]
GO:1990182 [exosomal secretion]
Show all
 221 aa
24.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.