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SCT

GENERAL INFORMATION

Gene name

 SCT

Gene description

 Secretin

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (duodenum, small intestine)
GTEx:Tissue enhanced (testis)
FANTOM5:Tissue enhanced (colon, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in small intestines.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA050961
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (duodenum, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, small intestine)

GENE INFORMATION

Gene name

 SCT

Synonyms

Description

 Secretin (HGNC Symbol)

Entrez gene summary

 Secretin belongs to the glucagon family. This protein is an endocrine hormone and its major site of production is the endocrine S cells located in the proximal small intestinal mucosa. The release of active secretin is stimulated by either fatty acids or an acidic pH in the duodenum. This hormone stimulates the secretion of bicarbonate-rich pancreatic fluids and has also been shown to regulate the growth and development of the stomach, small intestine, and pancreas. Secretin deficiency has been implicated in autistic syndrome, suggesting that the hormone could have a neuroendocrine function in addition to its role in digestion. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 626431 - 627143

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000070031 (version 83.38)

Entrez gene

 6343

UniProt

 P09683 (UniProt - Evidence at protein level)

neXtProt

 NX_P09683

Antibodypedia

 SCT antibodies

PROTEIN BROWSER
SCT-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SCT-001
ENSP00000176195
ENST00000176195
P09683 [Direct mapping]
Secretin
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005575 [cellular_component]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007420 [brain development]
GO:0008542 [visual learning]
GO:0021542 [dentate gyrus development]
GO:0030157 [pancreatic juice secretion]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0047485 [protein N-terminus binding]
GO:0048566 [embryonic digestive tract development]
GO:0090187 [positive regulation of pancreatic juice secretion]
GO:0090274 [positive regulation of somatostatin secretion]
GO:0097150 [neuronal stem cell population maintenance]
GO:1903640 [negative regulation of gastrin-induced gastric acid secretion]
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 121 aa
13 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.