Cell atlas - SMG6 - The Human Protein Atlas

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SMG6

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli

Human cell
	Cytosol
	Nucleoli

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GENERAL INFORMATION
Gene name	SMG6
Gene description	SMG6 nonsense mediated mRNA decay factor
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (supported)
Additional location	In addition localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA042932
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli. In addition localized to the cytosol.

Main location

Nucleoli (supported)

Additional location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA042932	A-431	Nucleoli
	HPA042932	A-431	Cytosol
	HPA042932	U-2 OS	Nucleoli
	HPA042932	U-2 OS	Cytosol
	HPA042932	U-251 MG	Nucleoli

GENE INFORMATION
Gene name	SMG6 (HGNC Symbol)
Synonyms	C17orf31, EST1A, KIAA0732, SMG-6
Description	SMG6 nonsense mediated mRNA decay factor (HGNC Symbol)
Entrez gene summary	This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014]
Chromosome	17
Cytoband	p13.3
Chromosome location (bp)	2059839 - 2303771
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000070366 (version 83.38)
Entrez gene	23293
UniProt	Q86US8 (UniProt - Evidence at protein level)
neXtProt	NX_Q86US8
Antibodypedia	SMG6 antibodies

PROTEIN BROWSER

SMG6-001	SMG6-002	SMG6-005	SMG6-008	SMG6-009	SMG6-010	SMG6-013	SMG6-014	SMG6-015	SMG6-018	SMG6-019	SMG6-021

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SMG6-001 ENSP00000263073 ENST00000263073	Q86US8 [Direct mapping] Telomerase-binding protein EST1A Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0000723 [telomere maintenance] GO:0000781 [chromosome, telomeric region] GO:0004521 [endoribonuclease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005697 [telomerase holoenzyme complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006406 [mRNA export from nucleus] GO:0010467 [gene expression] GO:0035145 [exon-exon junction complex] GO:0035303 [regulation of dephosphorylation] GO:0042162 [telomeric DNA binding] GO:0046872 [metal ion binding] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	1419 aa 160.5 kDa	No	0
SMG6-002 ENSP00000346977 ENST00000354901	Q86US8 [Direct mapping] Telomerase-binding protein EST1A Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0000723 [telomere maintenance] GO:0000781 [chromosome, telomeric region] GO:0004521 [endoribonuclease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005697 [telomerase holoenzyme complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006406 [mRNA export from nucleus] GO:0010467 [gene expression] GO:0035145 [exon-exon junction complex] GO:0035303 [regulation of dephosphorylation] GO:0042162 [telomeric DNA binding] GO:0046872 [metal ion binding] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	511 aa 57.5 kDa	No	0
SMG6-005 ENSP00000440283 ENST00000536871	Q86US8 [Direct mapping] Telomerase-binding protein EST1A Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0000723 [telomere maintenance] GO:0000781 [chromosome, telomeric region] GO:0004521 [endoribonuclease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005697 [telomerase holoenzyme complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006406 [mRNA export from nucleus] GO:0010467 [gene expression] GO:0035145 [exon-exon junction complex] GO:0035303 [regulation of dephosphorylation] GO:0042162 [telomeric DNA binding] GO:0046872 [metal ion binding] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	511 aa 57.5 kDa	No	0
SMG6-008 ENSP00000465793 ENST00000572369	K7EKV2 [Direct mapping] Telomerase-binding protein EST1A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		139 aa 15.6 kDa	No	0
SMG6-009 ENSP00000466139 ENST00000575176	K7ELM2 [Direct mapping] Telomerase-binding protein EST1A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		124 aa 14 kDa	No	0
SMG6-010 ENSP00000460273 ENST00000575454	I3L390 [Direct mapping] Telomerase-binding protein EST1A Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		208 aa 23.3 kDa	Yes	0
SMG6-013 ENSP00000460301 ENST00000570668	I3L3A9 [Direct mapping] Telomerase-binding protein EST1A Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		119 aa 13.3 kDa	No	0
SMG6-014 ENSP00000458635 ENST00000575663	I3L176 [Direct mapping] Telomerase-binding protein EST1A Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		162 aa 18.1 kDa	No	0
SMG6-015 ENSP00000459164 ENST00000571442	I3L1W8 [Direct mapping] Telomerase-binding protein EST1A Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		164 aa 18.3 kDa	No	0
SMG6-018 ENSP00000466951 ENST00000572205	K7ENH7 [Direct mapping] Telomerase-binding protein EST1A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		115 aa 13 kDa	No	0
SMG6-019 ENSP00000460898 ENST00000570659	I3L421 [Direct mapping] Telomerase-binding protein EST1A Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		163 aa 18.2 kDa	No	0
SMG6-021 ENSP00000460191 ENST00000570606	I3L355 [Direct mapping] Telomerase-binding protein EST1A Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		123 aa 13.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.