Tissue expression of FGF22 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FGF22
Gene description	Fibroblast growth factor 22
Protein class	Predicted secreted proteins RAS pathway related proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (skin)
GTEx:	Tissue enhanced (skin)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skin)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skin)

GENE INFORMATION
Gene name	FGF22
Synonyms
Description	Fibroblast growth factor 22 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	639879 - 644371
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000070388 (version 83.38)
Entrez gene	27006
UniProt	Q9HCT0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HCT0
Antibodypedia	FGF22 antibodies

PROTEIN BROWSER

FGF22-001	FGF22-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FGF22-001 ENSP00000215530 ENST00000215530	Q9HCT0 [Direct mapping] Fibroblast growth factor 22 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005730 [nucleolus] GO:0005794 [Golgi apparatus] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008083 [growth factor activity] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009986 [cell surface] GO:0030154 [cell differentiation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] Show all	170 aa 19.7 kDa	Yes	0
FGF22-002 ENSP00000466004 ENST00000586042	K7ELB9 [Direct mapping] Fibroblast growth factor Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Show all	GO:0005104 [fibroblast growth factor receptor binding] GO:0005576 [extracellular region] GO:0008083 [growth factor activity] GO:0008543 [fibroblast growth factor receptor signaling pathway] Show all	165 aa 18.2 kDa	Yes	0