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RNF126

GENERAL INFORMATION

Gene name

 RNF126

Gene description

 Ring finger protein 126

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA043050
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RNF126 (HGNC Symbol)

Synonyms

 FLJ20552

Description

 Ring finger protein 126 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 647526 - 663277

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000070423 (version 83.38)

Entrez gene

 55658

UniProt

 Q9BV68 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BV68

Antibodypedia

 RNF126 antibodies

PROTEIN BROWSER
RNF126-001
RNF126-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RNF126-001
ENSP00000292363
ENST00000292363
Q9BV68 [Direct mapping]
E3 ubiquitin-protein ligase RNF126
A0A024R206 [Target identity:100%; Query identity:100%]
Ring finger protein 126, isoform CRA_b
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005154 [epidermal growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006513 [protein monoubiquitination]
GO:0008270 [zinc ion binding]
GO:0016874 [ligase activity]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043162 [ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070534 [protein K63-linked ubiquitination]
GO:0070936 [protein K48-linked ubiquitination]
GO:0071629 [cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process]
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 311 aa
33.9 kDa 		No 0
RNF126-008
ENSP00000464945
ENST00000589762
K7EIY6 [Direct mapping]
E3 ubiquitin-protein ligase RNF126
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
 284 aa
30.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.