Expression of GBA2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Glucosidase, beta (bile acid) 2

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA024026

GENE INFORMATION
Gene name	GBA2 (HGNC Symbol)
Synonyms	AD035, DKFZp762K054, KIAA1605, SPG46
Description	Glucosidase, beta (bile acid) 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	p13.3
Chromosome location (bp)	35736866 - 35749228
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000070610 (version 83.38)
Entrez gene	57704
UniProt	Q9HCG7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HCG7
Antibodypedia	GBA2 antibodies

PROTEIN BROWSER

GBA2-001	GBA2-003	GBA2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GBA2-001 ENSP00000367343 ENST00000378103	Q9HCG7 [Direct mapping] Non-lysosomal glucosylceramidase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003824 [catalytic activity] GO:0004348 [glucosylceramidase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005790 [smooth endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006665 [sphingolipid metabolic process] GO:0006680 [glucosylceramide catabolic process] GO:0006687 [glycosphingolipid metabolic process] GO:0008206 [bile acid metabolic process] GO:0008422 [beta-glucosidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016139 [glycoside catabolic process] GO:0021954 [central nervous system neuron development] GO:0044281 [small molecule metabolic process] Show all	927 aa 104.6 kDa	No	0
GBA2-003 ENSP00000367334 ENST00000378094	Q9HCG7 [Direct mapping] Non-lysosomal glucosylceramidase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003824 [catalytic activity] GO:0004348 [glucosylceramidase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005790 [smooth endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006665 [sphingolipid metabolic process] GO:0006680 [glucosylceramide catabolic process] GO:0006687 [glycosphingolipid metabolic process] GO:0008206 [bile acid metabolic process] GO:0008422 [beta-glucosidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016139 [glycoside catabolic process] GO:0021954 [central nervous system neuron development] GO:0044281 [small molecule metabolic process] Show all	877 aa 98.7 kDa	No	0
GBA2-004 ENSP00000367328 ENST00000378088	A0A0A0MRV1 [Direct mapping] Non-lysosomal glucosylceramidase Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004348 [glucosylceramidase activity] GO:0006665 [sphingolipid metabolic process] GO:0016021 [integral component of membrane] Show all	172 aa 18.5 kDa	No	0