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CNGB1

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GENERAL INFORMATION

Gene name

 CNGB1

Gene description

 Cyclic nucleotide gated channel beta 1

Protein class

 Disease related genes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to vesicles.

RNA cell category

 Cell line enhanced (SiHa, SCLC-21H)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (approved)

Additional location

 In addition localized to the Vesicles (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 2 antibodies.
HPA039159 , HPA060355
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SiHa, SCLC-21H)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to vesicles.

Main location

 Cytosol (approved)

Additional location

 Vesicles (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA039159 A-431 Vesicles
Cytosol
HPA039159 U-2 OS Vesicles
Cytosol
HPA039159 U-251 MG Cytosol
HPA060355 A549 Cytosol Intensity
HPA060355 SiHa Plasma membrane
Cytosol
HPA060355 U-2 OS Cytosol

GENE INFORMATION

Gene name

 CNGB1 (HGNC Symbol)

Synonyms

 CNCG2, CNCG3L, CNGB1B, GAR1, GARP, RCNC2, RCNCb, RP45

Description

 Cyclic nucleotide gated channel beta 1 (HGNC Symbol)

Entrez gene summary

 In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

Chromosome

 16

Cytoband

 q21

Chromosome location (bp)

 57882340 - 57971116

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000070729 (version 83.38)

Entrez gene

 1258

UniProt

 Q14028 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14028

Antibodypedia

 CNGB1 antibodies

PROTEIN BROWSER
CNGB1-001
CNGB1-002
CNGB1-003
CNGB1-004
CNGB1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CNGB1-001
ENSP00000251102
ENST00000251102
Q14028 [Direct mapping]
Cyclic nucleotide-gated cation channel beta-1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001750 [photoreceptor outer segment]
GO:0001895 [retina homeostasis]
GO:0005222 [intracellular cAMP activated cation channel activity]
GO:0005223 [intracellular cGMP activated cation channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006812 [cation transport]
GO:0006996 [organelle organization]
GO:0007601 [visual perception]
GO:0007602 [phototransduction]
GO:0007603 [phototransduction, visible light]
GO:0007608 [sensory perception of smell]
GO:0015276 [ligand-gated ion channel activity]
GO:0016020 [membrane]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030552 [cAMP binding]
GO:0030553 [cGMP binding]
GO:0030660 [Golgi-associated vesicle membrane]
GO:0033365 [protein localization to organelle]
GO:0035845 [photoreceptor cell outer segment organization]
GO:0042391 [regulation of membrane potential]
GO:0043855 [cyclic nucleotide-gated ion channel activity]
GO:0045494 [photoreceptor cell maintenance]
GO:0050908 [detection of light stimulus involved in visual perception]
GO:0060170 [ciliary membrane]
GO:0071805 [potassium ion transmembrane transport]
GO:1902495 [transmembrane transporter complex]
Show all
 1251 aa
139.7 kDa 		No 5
CNGB1-002
ENSP00000311670
ENST00000311183
Q14028 [Direct mapping]
Cyclic nucleotide-gated cation channel beta-1
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001895 [retina homeostasis]
GO:0005222 [intracellular cAMP activated cation channel activity]
GO:0005223 [intracellular cGMP activated cation channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006812 [cation transport]
GO:0006996 [organelle organization]
GO:0007601 [visual perception]
GO:0007603 [phototransduction, visible light]
GO:0015276 [ligand-gated ion channel activity]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030552 [cAMP binding]
GO:0030553 [cGMP binding]
GO:0030660 [Golgi-associated vesicle membrane]
GO:0042391 [regulation of membrane potential]
GO:0050908 [detection of light stimulus involved in visual perception]
GO:0060170 [ciliary membrane]
GO:0071805 [potassium ion transmembrane transport]
GO:1902495 [transmembrane transporter complex]
Show all
 299 aa
32.5 kDa 		No 0
CNGB1-003
ENSP00000454633
ENST00000564448
Q14028 [Direct mapping]
Cyclic nucleotide-gated cation channel beta-1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Show all
GO:0000139 [Golgi membrane]
GO:0001895 [retina homeostasis]
GO:0005222 [intracellular cAMP activated cation channel activity]
GO:0005223 [intracellular cGMP activated cation channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006812 [cation transport]
GO:0006996 [organelle organization]
GO:0007601 [visual perception]
GO:0007603 [phototransduction, visible light]
GO:0015276 [ligand-gated ion channel activity]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030552 [cAMP binding]
GO:0030553 [cGMP binding]
GO:0030660 [Golgi-associated vesicle membrane]
GO:0042391 [regulation of membrane potential]
GO:0050908 [detection of light stimulus involved in visual perception]
GO:0060170 [ciliary membrane]
GO:0071805 [potassium ion transmembrane transport]
GO:1902495 [transmembrane transporter complex]
Show all
 1245 aa
139.2 kDa 		No 5
CNGB1-004
ENSP00000455708
ENST00000562761
H3BQC3 [Direct mapping]
Cyclic nucleotide-gated cation channel beta-1
Show all
Predicted intracellular proteins
Show all
GO:0005222 [intracellular cAMP activated cation channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0042391 [regulation of membrane potential]
GO:0071805 [potassium ion transmembrane transport]
Show all
 214 aa
23.5 kDa 		No 0
CNGB1-008
ENSP00000455964
ENST00000565942
H3BQW3 [Direct mapping]
Cyclic nucleotide-gated cation channel beta-1
Show all
Predicted intracellular proteins
Show all
GO:0005222 [intracellular cAMP activated cation channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0042391 [regulation of membrane potential]
GO:0071805 [potassium ion transmembrane transport]
Show all
 127 aa
13.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.