Expression of TRPM5 in cancer - Summary

CANCER ATLAS

Gene description

Transient receptor potential cation channel, subfamily M, member 5

Protein class

Predicted membrane proteins, Transporters, Voltage-gated ion channels

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Glioma

STAINING SUMMARY

HPA042115	HPA043315

GENE INFORMATION
Gene name	TRPM5 (HGNC Symbol)
Synonyms	LTRPC5, MTR1
Description	Transient receptor potential cation channel, subfamily M, member 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010]
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	2404515 - 2423045
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000070985 (version 83.38)
Entrez gene	29850
UniProt	Q9NZQ8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NZQ8
Antibodypedia	TRPM5 antibodies

PROTEIN BROWSER

TRPM5-001	TRPM5-002	TRPM5-003	TRPM5-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRPM5-001 ENSP00000155858 ENST00000155858	Q9NZQ8 [Direct mapping] Transient receptor potential cation channel subfamily M member 5 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005227 [calcium activated cation channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005267 [potassium channel activity] GO:0005272 [sodium channel activity] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030425 [dendrite] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0043025 [neuronal cell body] GO:0050909 [sensory perception of taste] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0071805 [potassium ion transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	1165 aa 131.5 kDa	No	6
TRPM5-002 ENSP00000434383 ENST00000533881	A0A0C4DGF4 [Direct mapping] Transient receptor potential cation channel subfamily M member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	1159 aa 130.8 kDa	No	6
TRPM5-003 ENSP00000434121 ENST00000533060	E9PRW0 [Direct mapping] Transient receptor potential cation channel subfamily M member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005227 [calcium activated cation channel activity] GO:0016021 [integral component of membrane] GO:0050909 [sensory perception of taste] GO:0098655 [cation transmembrane transport] Show all	1173 aa 132.3 kDa	No	6
TRPM5-004 ENSP00000436809 ENST00000528453	E9PQF7 [Direct mapping] Transient receptor potential cation channel subfamily M member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005227 [calcium activated cation channel activity] GO:0016021 [integral component of membrane] GO:0050909 [sensory perception of taste] GO:0098655 [cation transmembrane transport] Show all	1166 aa 131.5 kDa	No	6