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ING3

CANCER ATLAS

Gene description

 Inhibitor of growth family, member 3

Protein class

 Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA067388

GENE INFORMATION

Gene name

 ING3 (HGNC Symbol)

Synonyms

 Eaf4, FLJ20089, MEAF4, p47ING3

Description

 Inhibitor of growth family, member 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q31.31

Chromosome location (bp)

 120950749 - 120977216

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000071243 (version 83.38)

Entrez gene

 54556

UniProt

 Q9NXR8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NXR8

Antibodypedia

 ING3 antibodies

PROTEIN BROWSER
ING3-001
ING3-002
ING3-003
ING3-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ING3-001
ENSP00000320566
ENST00000315870
Q9NXR8 [Direct mapping]
Inhibitor of growth protein 3
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000812 [Swr1 complex]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0032777 [Piccolo NuA4 histone acetyltransferase complex]
GO:0035064 [methylated histone binding]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0043065 [positive regulation of apoptotic process]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
Show all
 418 aa
46.7 kDa 		No 0
ING3-002
ENSP00000341697
ENST00000339121
Q9NXR8 [Direct mapping]
Inhibitor of growth protein 3
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000812 [Swr1 complex]
GO:0004402 [histone acetyltransferase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0032777 [Piccolo NuA4 histone acetyltransferase complex]
GO:0035064 [methylated histone binding]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0043065 [positive regulation of apoptotic process]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
Show all
 92 aa
11.3 kDa 		No 0
ING3-003
ENSP00000395719
ENST00000445699
A0A0C4DG38 [Direct mapping]
Inhibitor of growth protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0016568 [chromatin modification]
Show all
 99 aa
12 kDa 		No 0
ING3-006
ENSP00000388506
ENST00000431467
E7ET07 [Direct mapping]
Inhibitor of growth protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0016568 [chromatin modification]
Show all
 403 aa
44.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.