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LMCD1

CANCER ATLAS

Gene description

 LIM and cysteine-rich domains 1

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024059

GENE INFORMATION

Gene name

 LMCD1

Synonyms

Description

 LIM and cysteine-rich domains 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the LIM-domain family of zinc finger proteins. The encoded protein contains an N-terminal cysteine-rich domain and two C-terminal LIM domains. The presence of LIM domains suggests involvement in protein-protein interactions. The protein may act as a co-regulator of transcription along with other transcription factors. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Chromosome

 3

Cytoband

 p25.3

Chromosome location (bp)

 8501707 - 8574673

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000071282 (version 83.38)

Entrez gene

 29995

UniProt

 Q9NZU5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZU5

Antibodypedia

 LMCD1 antibodies

PROTEIN BROWSER
LMCD1-001
LMCD1-002
LMCD1-004
LMCD1-006
LMCD1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LMCD1-001
ENSP00000157600
ENST00000157600
Q9NZU5 [Direct mapping]
LIM and cysteine-rich domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0010611 [regulation of cardiac muscle hypertrophy]
GO:0031012 [extracellular matrix]
GO:0044267 [cellular protein metabolic process]
GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 365 aa
40.8 kDa 		No 0
LMCD1-002
ENSP00000396515
ENST00000454244
Q9NZU5 [Direct mapping]
LIM and cysteine-rich domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003714 [transcription corepressor activity]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0010611 [regulation of cardiac muscle hypertrophy]
GO:0031012 [extracellular matrix]
GO:0044267 [cellular protein metabolic process]
GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 292 aa
32.9 kDa 		No 0
LMCD1-004
ENSP00000400555
ENST00000415597
C9IYS1 [Direct mapping]
LIM and cysteine-rich domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003714 [transcription corepressor activity]
GO:0005634 [nucleus]
GO:0008270 [zinc ion binding]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 234 aa
26.2 kDa 		No 0
LMCD1-006
ENSP00000411222
ENST00000426878
H7C3D2 [Direct mapping]
LIM and cysteine-rich domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003714 [transcription corepressor activity]
GO:0005634 [nucleus]
GO:0008270 [zinc ion binding]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 247 aa
27.4 kDa 		No 0
LMCD1-201
ENSP00000380542
ENST00000397386
B4DEY6 [Direct mapping]
LIM and cysteine-rich domains protein 1; cDNA FLJ52480, highly similar to LIM and cysteine-rich domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003714 [transcription corepressor activity]
GO:0005634 [nucleus]
GO:0008270 [zinc ion binding]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 253 aa
28.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.