Cell atlas - ATP6AP1 - The Human Protein Atlas

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ATP6AP1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Microtubules
	Plasma membrane

Human cell
	Cytosol
	Microtubules
	Plasma Membrane

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GENERAL INFORMATION
Gene name	ATP6AP1
Gene description	ATPase, H+ transporting, lysosomal accessory protein 1
Protein class	Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane, cytosol & microtubules.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Microtubules (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. CAB015218
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane, cytosol & microtubules.

Main location

Plasma membrane (approved), Microtubules (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB015218	A-431	Microtubules
	CAB015218	U-2 OS	Plasma membrane
	CAB015218	U-2 OS	Cytosol
	CAB015218	U-251 MG	Plasma membrane
	CAB015218	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ATP6AP1 (HGNC Symbol)
Synonyms	16A, Ac45, ATP6IP1, ATP6S1, CF2, ORF, VATPS1, XAP-3, XAP3
Description	ATPase, H+ transporting, lysosomal accessory protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	154428632 - 154436516
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000071553 (version 83.38)
Entrez gene	537
UniProt	Q15904 (UniProt - Evidence at protein level)
neXtProt	NX_Q15904
Antibodypedia	ATP6AP1 antibodies

PROTEIN BROWSER

ATP6AP1-001	ATP6AP1-003	ATP6AP1-010	ATP6AP1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP6AP1-001 ENSP00000358777 ENST00000369762	Q15904 [Direct mapping] V-type proton ATPase subunit S1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005524 [ATP binding] GO:0005774 [vacuolar membrane] GO:0006879 [cellular iron ion homeostasis] GO:0008286 [insulin receptor signaling pathway] GO:0010008 [endosome membrane] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0016469 [proton-transporting two-sector ATPase complex] GO:0017137 [Rab GTPase binding] GO:0033180 [proton-transporting V-type ATPase, V1 domain] GO:0033572 [transferrin transport] GO:0034220 [ion transmembrane transport] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045780 [positive regulation of bone resorption] GO:0045851 [pH reduction] GO:0045921 [positive regulation of exocytosis] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0051656 [establishment of organelle localization] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:2001206 [positive regulation of osteoclast development] Show all	470 aa 52 kDa	Yes	1
ATP6AP1-003 ENSP00000398511 ENST00000422890	A6NLC6 [Direct mapping] V-type proton ATPase subunit S1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0015991 [ATP hydrolysis coupled proton transport] GO:0033180 [proton-transporting V-type ATPase, V1 domain] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] Show all	273 aa 30.1 kDa	Yes	0
ATP6AP1-010 ENSP00000392375 ENST00000449556	A6QRJ1 [Direct mapping] V-type proton ATPase subunit S1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0015991 [ATP hydrolysis coupled proton transport] GO:0033180 [proton-transporting V-type ATPase, V1 domain] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] Show all	230 aa 24.9 kDa	Yes	0
ATP6AP1-201 ENSP00000482243 ENST00000619046	A0A0C4DGX8 [Direct mapping] ATPase, H+ transporting, lysosomal accessory protein 1, isoform CRA_c; V-type proton ATPase subunit S1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0033180 [proton-transporting V-type ATPase, V1 domain] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] Show all	281 aa 31.6 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.