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TRIB2

CANCER ATLAS

Gene description

 Tribbles pseudokinase 2

Protein class

 Enzymes, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA001305

GENE INFORMATION

Gene name

 TRIB2 (HGNC Symbol)

Synonyms

 GS3955, TRB2

Description

 Tribbles pseudokinase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

 2

Cytoband

 p24.3

Chromosome location (bp)

 12716889 - 12742734

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000071575 (version 83.38)

Entrez gene

 28951

UniProt

 Q92519 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q92519

Antibodypedia

 TRIB2 antibodies

PROTEIN BROWSER
TRIB2-001
TRIB2-002
TRIB2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRIB2-001
ENSP00000155926
ENST00000155926
Q92519 [Direct mapping]
Tribbles homolog 2
Show all
Enzymes
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004672 [protein kinase activity]
GO:0004860 [protein kinase inhibitor activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0008134 [transcription factor binding]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0043405 [regulation of MAP kinase activity]
GO:0045081 [negative regulation of interleukin-10 biosynthetic process]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0055106 [ubiquitin-protein transferase regulator activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 343 aa
38.8 kDa 		No 1
TRIB2-002
ENSP00000370874
ENST00000381465
F8WA18 [Direct mapping]
Tribbles homolog 2; cDNA FLJ57420
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006468 [protein phosphorylation]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0043405 [regulation of MAP kinase activity]
Show all
 207 aa
23.6 kDa 		No 1
TRIB2-004
ENSP00000384260
ENST00000405331
B5MCX4 [Direct mapping]
Tribbles homolog 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006468 [protein phosphorylation]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0043405 [regulation of MAP kinase activity]
Show all
 252 aa
28.5 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.