Cell atlas - EPN2 - The Human Protein Atlas

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EPN2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	EPN2
Gene description	Epsin 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	16
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA053360
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA053360	A549	Vesicles
	HPA053360	U-2 OS	Vesicles

GENE INFORMATION
Gene name	EPN2 (HGNC Symbol)
Synonyms	EHB21, KIAA1065
Description	Epsin 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	19215615 - 19336715
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000072134 (version 83.38)
Entrez gene	22905
UniProt	O95208 (UniProt - Evidence at protein level)
neXtProt	NX_O95208
Antibodypedia	EPN2 antibodies

PROTEIN BROWSER

EPN2-001	EPN2-003	EPN2-004	EPN2-007	EPN2-008	EPN2-009	EPN2-010	EPN2-012	EPN2-013	EPN2-016	EPN2-017	EPN2-020	EPN2-021	EPN2-026	EPN2-029	EPN2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EPN2-001 ENSP00000320543 ENST00000314728	O95208 [Direct mapping] Epsin-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001701 [in utero embryonic development] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0006897 [endocytosis] GO:0007219 [Notch signaling pathway] GO:0008289 [lipid binding] GO:0030100 [regulation of endocytosis] GO:0030128 [clathrin coat of endocytic vesicle] GO:0043231 [intracellular membrane-bounded organelle] GO:0048568 [embryonic organ development] Show all	641 aa 68.5 kDa	No	0
EPN2-003 ENSP00000378980 ENST00000395618	O95208 [Direct mapping] Epsin-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0006897 [endocytosis] GO:0008289 [lipid binding] GO:0043231 [intracellular membrane-bounded organelle] Show all	356 aa 36.7 kDa	No	0
EPN2-004 ENSP00000378988 ENST00000395626	E9PBC1 [Direct mapping] Epsin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0006897 [endocytosis] GO:0030128 [clathrin coat of endocytic vesicle] GO:0043231 [intracellular membrane-bounded organelle] Show all	484 aa 53 kDa	No	0
EPN2-007 ENSP00000378982 ENST00000395620	O95208 [Direct mapping] Epsin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0006897 [endocytosis] GO:0008289 [lipid binding] GO:0043231 [intracellular membrane-bounded organelle] Show all	584 aa 62.3 kDa	No	0
EPN2-008 ENSP00000460193 ENST00000494192	I3L356 [Direct mapping] Epsin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] Show all	251 aa 26.5 kDa	No	0
EPN2-009 ENSP00000459678 ENST00000575595	I3L2H1 [Direct mapping] Epsin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] Show all	349 aa 36 kDa	No	0
EPN2-010 ENSP00000459542 ENST00000571254	I3L2B2 [Direct mapping] Epsin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] Show all	577 aa 61.6 kDa	No	0
EPN2-012 ENSP00000378990 ENST00000395628	F6PQP6 [Direct mapping] Epsin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0006897 [endocytosis] GO:0030128 [clathrin coat of endocytic vesicle] Show all	410 aa 45 kDa	No	0
EPN2-013 ENSP00000462465 ENST00000582015	J3KSF8 [Direct mapping] Epsin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006897 [endocytosis] GO:0030128 [clathrin coat of endocytic vesicle] Show all	32 aa 3.7 kDa	No	0
EPN2-016 ENSP00000462392 ENST00000577195	J3KSA6 [Direct mapping] Epsin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006897 [endocytosis] GO:0030128 [clathrin coat of endocytic vesicle] Show all	62 aa 7.1 kDa	No	0
EPN2-017 ENSP00000462606 ENST00000584150	J3KSR0 [Direct mapping] Epsin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		20 aa 2.3 kDa	No	0
EPN2-020 ENSP00000462426 ENST00000584633	J3KSC7 [Direct mapping] Epsin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006897 [endocytosis] GO:0030128 [clathrin coat of endocytic vesicle] Show all	75 aa 8.7 kDa	No	0
EPN2-021 ENSP00000463141 ENST00000583197	J3QKL8 [Direct mapping] Epsin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		22 aa 2.6 kDa	No	0
EPN2-026 ENSP00000462958 ENST00000581024	J3KTF6 [Direct mapping] Epsin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006897 [endocytosis] GO:0030128 [clathrin coat of endocytic vesicle] Show all	38 aa 4.3 kDa	No	0
EPN2-029 ENSP00000463627 ENST00000577692	J3QLN2 [Direct mapping] Epsin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006897 [endocytosis] GO:0030128 [clathrin coat of endocytic vesicle] Show all	95 aa 11 kDa	No	0
EPN2-201 ENSP00000261495 ENST00000347697	O95208 [Direct mapping] Epsin-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0006897 [endocytosis] GO:0008289 [lipid binding] GO:0043231 [intracellular membrane-bounded organelle] Show all	584 aa 62.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.