Tissue expression of ASIC4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ASIC4
Gene description	Acid sensing (proton gated) ion channel family member 4
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Tissue enhanced (pituitary gland)
FANTOM5:	Tissue enhanced (pituitary gland)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (pituitary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (pituitary gland)

GENE INFORMATION
Gene name	ASIC4 (HGNC Symbol)
Synonyms	ACCN4, BNAC4
Description	Acid sensing (proton gated) ion channel family member 4 (HGNC Symbol)
Entrez gene summary	This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012]
Chromosome	2
Cytoband	q35
Chromosome location (bp)	219514170 - 219538772
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000072182 (version 83.38)
Entrez gene	55515
UniProt	Q96FT7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96FT7
Antibodypedia	ASIC4 antibodies

PROTEIN BROWSER

ASIC4-001	ASIC4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASIC4-001 ENSP00000326627 ENST00000347842	Q96FT7 [Direct mapping] Acid-sensing ion channel 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005272 [sodium channel activity] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0015081 [sodium ion transmembrane transporter activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] Show all	647 aa 70.1 kDa	No	2
ASIC4-002 ENSP00000350786 ENST00000358078	Q96FT7 [Direct mapping] Acid-sensing ion channel 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005272 [sodium channel activity] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0015081 [sodium ion transmembrane transporter activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] Show all	666 aa 72.2 kDa	No	2