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ALDH3A2

CANCER ATLAS

Gene description

 Aldehyde dehydrogenase 3 family, member A2

Protein class

 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA014769
CAB020692

GENE INFORMATION

Gene name

 ALDH3A2 (HGNC Symbol)

Synonyms

 ALDH10, ALDH3A2, FALDH , SLS

Description

 Aldehyde dehydrogenase 3 family, member A2 (HGNC Symbol)

Entrez gene summary

 Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p11.2

Chromosome location (bp)

 19648136 - 19677598

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000072210 (version 83.38)

Entrez gene

 224

UniProt

 P51648 (UniProt - Evidence at protein level)

neXtProt

 NX_P51648

Antibodypedia

 ALDH3A2 antibodies

PROTEIN BROWSER
«
ALDH3A2-001
ALDH3A2-002
ALDH3A2-004
ALDH3A2-006
ALDH3A2-008
ALDH3A2-010
ALDH3A2-012
ALDH3A2-017
ALDH3A2-018
ALDH3A2-020
ALDH3A2-022
ALDH3A2-024
ALDH3A2-201
ALDH3A2-202
ALDH3A2-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALDH3A2-001
ENSP00000176643
ENST00000176643
P51648 [Direct mapping]
Fatty aldehyde dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity]
GO:0005777 [peroxisome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0006714 [sesquiterpenoid metabolic process]
GO:0007417 [central nervous system development]
GO:0007422 [peripheral nervous system development]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0016491 [oxidoreductase activity]
GO:0030148 [sphingolipid biosynthetic process]
GO:0033306 [phytol metabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0046577 [long-chain-alcohol oxidase activity]
GO:0050061 [long-chain-aldehyde dehydrogenase activity]
GO:0052814 [medium-chain-aldehyde dehydrogenase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 485 aa
54.8 kDa 		No 3
ALDH3A2-002
ENSP00000345774
ENST00000339618
P51648 [Direct mapping]
Fatty aldehyde dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005777 [peroxisome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0006714 [sesquiterpenoid metabolic process]
GO:0007417 [central nervous system development]
GO:0007422 [peripheral nervous system development]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0030148 [sphingolipid biosynthetic process]
GO:0033306 [phytol metabolic process]
GO:0042406 [extrinsic component of endoplasmic reticulum membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0046292 [formaldehyde metabolic process]
GO:0046577 [long-chain-alcohol oxidase activity]
GO:0050061 [long-chain-aldehyde dehydrogenase activity]
GO:0052814 [medium-chain-aldehyde dehydrogenase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 508 aa
57.7 kDa 		No 3
ALDH3A2-004
ENSP00000378942
ENST00000395575
P51648 [Direct mapping]
Fatty aldehyde dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity]
GO:0005777 [peroxisome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0006714 [sesquiterpenoid metabolic process]
GO:0007417 [central nervous system development]
GO:0007422 [peripheral nervous system development]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0016491 [oxidoreductase activity]
GO:0030148 [sphingolipid biosynthetic process]
GO:0033306 [phytol metabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0046577 [long-chain-alcohol oxidase activity]
GO:0050061 [long-chain-aldehyde dehydrogenase activity]
GO:0052814 [medium-chain-aldehyde dehydrogenase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 485 aa
54.8 kDa 		No 3
ALDH3A2-006
ENSP00000395845
ENST00000446398
C9JGJ2 [Direct mapping]
Fatty aldehyde dehydrogenase
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 166 aa
18.7 kDa 		No 0
ALDH3A2-008
ENSP00000458942
ENST00000571537
I3L1M4 [Direct mapping]
Fatty aldehyde dehydrogenase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 162 aa
18.5 kDa 		No 0
ALDH3A2-010
ENSP00000459977
ENST00000571163
I3L2W1 [Direct mapping]
Fatty aldehyde dehydrogenase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 97 aa
10.8 kDa 		No 0
ALDH3A2-012
ENSP00000461235
ENST00000575384
I3L4G6 [Direct mapping]
Fatty aldehyde dehydrogenase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0016021 [integral component of membrane]
GO:0055114 [oxidation-reduction process]
Show all
 85 aa
9.6 kDa 		No 1
ALDH3A2-017
ENSP00000462964
ENST00000580550
J3KTG1 [Direct mapping]
Fatty aldehyde dehydrogenase
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 146 aa
16.5 kDa 		No 0
ALDH3A2-018
ENSP00000466814
ENST00000584332
K7EN73 [Direct mapping]
Fatty aldehyde dehydrogenase
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 127 aa
14.1 kDa 		No 0
ALDH3A2-020
ENSP00000464453
ENST00000578696
J3QS00 [Direct mapping]
Fatty aldehyde dehydrogenase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 134 aa
15.1 kDa 		No 0
ALDH3A2-022
ENSP00000463637
ENST00000579855
P51648 [Direct mapping]
Fatty aldehyde dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity]
GO:0005777 [peroxisome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0006714 [sesquiterpenoid metabolic process]
GO:0007417 [central nervous system development]
GO:0007422 [peripheral nervous system development]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0016491 [oxidoreductase activity]
GO:0030148 [sphingolipid biosynthetic process]
GO:0033306 [phytol metabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0046577 [long-chain-alcohol oxidase activity]
GO:0050061 [long-chain-aldehyde dehydrogenase activity]
GO:0052814 [medium-chain-aldehyde dehydrogenase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 485 aa
54.8 kDa 		No 3
ALDH3A2-024
ENSP00000461916
ENST00000581518
P51648 [Direct mapping]
Fatty aldehyde dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity]
GO:0005777 [peroxisome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0006714 [sesquiterpenoid metabolic process]
GO:0007417 [central nervous system development]
GO:0007422 [peripheral nervous system development]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0016491 [oxidoreductase activity]
GO:0030148 [sphingolipid biosynthetic process]
GO:0033306 [phytol metabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0046577 [long-chain-alcohol oxidase activity]
GO:0050061 [long-chain-aldehyde dehydrogenase activity]
GO:0052814 [medium-chain-aldehyde dehydrogenase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 508 aa
57.7 kDa 		No 4
ALDH3A2-201
ENSP00000486283
ENST00000626500
I3L0X1 [Direct mapping]
Fatty aldehyde dehydrogenase
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 182 aa
20.7 kDa 		No 0
ALDH3A2-202
ENSP00000487353
ENST00000630662
I3L2W1 [Direct mapping]
Fatty aldehyde dehydrogenase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 97 aa
10.8 kDa 		No 0
ALDH3A2-203
ENSP00000486085
ENST00000631291
J3QRD1 [Direct mapping]
Fatty aldehyde dehydrogenase
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 393 aa
44.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.