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MARK2

CANCER ATLAS

Gene description

 MAP/microtubule affinity-regulating kinase 2

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038790

GENE INFORMATION

Gene name

 MARK2 (HGNC Symbol)

Synonyms

 EMK1, PAR-1, PAR-1B, Par1b

Description

 MAP/microtubule affinity-regulating kinase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 63838928 - 63911019

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000072518 (version 83.38)

Entrez gene

 2011

UniProt

 Q7KZI7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7KZI7

Antibodypedia

 MARK2 antibodies

PROTEIN BROWSER
«
MARK2-001
MARK2-002
MARK2-003
MARK2-005
MARK2-006
MARK2-009
MARK2-010
MARK2-012
MARK2-013
MARK2-014
MARK2-015
MARK2-016
MARK2-201
MARK2-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MARK2-001
ENSP00000425765
ENST00000508192
Q7KZI7 [Direct mapping]
Serine/threonine-protein kinase MARK2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0000422 [mitophagy]
GO:0001764 [neuron migration]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0008289 [lipid binding]
GO:0010976 [positive regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016328 [lateral plasma membrane]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0030010 [establishment of cell polarity]
GO:0030295 [protein kinase activator activity]
GO:0032147 [activation of protein kinase activity]
GO:0035556 [intracellular signal transduction]
GO:0044822 [poly(A) RNA binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0046777 [protein autophosphorylation]
GO:0050321 [tau-protein kinase activity]
GO:0050770 [regulation of axonogenesis]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051646 [mitochondrion localization]
GO:0097427 [microtubule bundle]
Show all
 724 aa
81.2 kDa 		No 0
MARK2-002
ENSP00000423452
ENST00000502399
E9PC69 [Direct mapping]
Serine/threonine-protein kinase MARK2
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 778 aa
86.7 kDa 		No 0
MARK2-003
ENSP00000423974
ENST00000509502
Q7KZI7 [Direct mapping]
Serine/threonine-protein kinase MARK2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0000422 [mitophagy]
GO:0001764 [neuron migration]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0008289 [lipid binding]
GO:0010976 [positive regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016328 [lateral plasma membrane]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0030010 [establishment of cell polarity]
GO:0030295 [protein kinase activator activity]
GO:0032147 [activation of protein kinase activity]
GO:0035556 [intracellular signal transduction]
GO:0044822 [poly(A) RNA binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0046777 [protein autophosphorylation]
GO:0050321 [tau-protein kinase activity]
GO:0050770 [regulation of axonogenesis]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051646 [mitochondrion localization]
GO:0097427 [microtubule bundle]
Show all
 745 aa
83.1 kDa 		No 0
MARK2-005
ENSP00000423844
ENST00000512060
Q5DNC5 [Direct mapping]
Ser/thr protein kinase Emk1/MARK2 isoform EMK1C; Serine/threonine-protein kinase MARK2
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 61 aa
6.5 kDa 		No 0
MARK2-006
ENSP00000421075
ENST00000513765
Q7KZI7 [Direct mapping]
Serine/threonine-protein kinase MARK2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0000422 [mitophagy]
GO:0001764 [neuron migration]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0008289 [lipid binding]
GO:0010976 [positive regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016328 [lateral plasma membrane]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0030010 [establishment of cell polarity]
GO:0030295 [protein kinase activator activity]
GO:0032147 [activation of protein kinase activity]
GO:0035556 [intracellular signal transduction]
GO:0044822 [poly(A) RNA binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0046777 [protein autophosphorylation]
GO:0050321 [tau-protein kinase activity]
GO:0050770 [regulation of axonogenesis]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051646 [mitochondrion localization]
GO:0097427 [microtubule bundle]
Show all
 755 aa
84.3 kDa 		No 0
MARK2-009
ENSP00000294247
ENST00000350490
Q7KZI7 [Direct mapping]
Serine/threonine-protein kinase MARK2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0000422 [mitophagy]
GO:0001764 [neuron migration]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0008289 [lipid binding]
GO:0010976 [positive regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016328 [lateral plasma membrane]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0030010 [establishment of cell polarity]
GO:0030295 [protein kinase activator activity]
GO:0032147 [activation of protein kinase activity]
GO:0035556 [intracellular signal transduction]
GO:0044822 [poly(A) RNA binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0046777 [protein autophosphorylation]
GO:0050321 [tau-protein kinase activity]
GO:0050770 [regulation of axonogenesis]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051646 [mitochondrion localization]
GO:0097427 [microtubule bundle]
Show all
 709 aa
79.4 kDa 		No 0
MARK2-010
ENSP00000355091
ENST00000361128
Q7KZI7 [Direct mapping]
Serine/threonine-protein kinase MARK2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0000422 [mitophagy]
GO:0001764 [neuron migration]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0008289 [lipid binding]
GO:0010976 [positive regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016328 [lateral plasma membrane]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0030010 [establishment of cell polarity]
GO:0030295 [protein kinase activator activity]
GO:0032147 [activation of protein kinase activity]
GO:0035556 [intracellular signal transduction]
GO:0044822 [poly(A) RNA binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0046777 [protein autophosphorylation]
GO:0050321 [tau-protein kinase activity]
GO:0050770 [regulation of axonogenesis]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051646 [mitochondrion localization]
GO:0097427 [microtubule bundle]
Show all
 719 aa
80.6 kDa 		No 0
MARK2-012
ENSP00000415494
ENST00000425897
E7ETY4 [Direct mapping]
Serine/threonine-protein kinase MARK2
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 699 aa
78.5 kDa 		No 0
MARK2-013
ENSP00000444956
ENST00000543220
F5H4F6 [Direct mapping]
Serine/threonine-protein kinase MARK2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 161 aa
18.5 kDa 		No 0
MARK2-014
ENSP00000444859
ENST00000543674
F5H4J8 [Direct mapping]
Serine/threonine-protein kinase MARK2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 91 aa
10.1 kDa 		No 0
MARK2-015
ENSP00000437509
ENST00000540169
F5H6N2 [Direct mapping]
Serine/threonine-protein kinase MARK2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 112 aa
12.6 kDa 		No 0
MARK2-016
ENSP00000386128
ENST00000408948
Q7KZI7 [Direct mapping]
Serine/threonine-protein kinase MARK2
A0A024R5B2 [Target identity:100%; Query identity:100%]
MAP/microtubule affinity-regulating kinase 2, isoform CRA_c
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0000422 [mitophagy]
GO:0001764 [neuron migration]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0008289 [lipid binding]
GO:0010976 [positive regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016328 [lateral plasma membrane]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0030010 [establishment of cell polarity]
GO:0030295 [protein kinase activator activity]
GO:0032147 [activation of protein kinase activity]
GO:0035556 [intracellular signal transduction]
GO:0044822 [poly(A) RNA binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0046777 [protein autophosphorylation]
GO:0050321 [tau-protein kinase activity]
GO:0050770 [regulation of axonogenesis]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051646 [mitochondrion localization]
GO:0097427 [microtubule bundle]
Show all
 691 aa
77.6 kDa 		No 0
MARK2-201
ENSP00000367041
ENST00000377810
E7ETY4 [Direct mapping]
Serine/threonine-protein kinase MARK2
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 699 aa
78.5 kDa 		No 0
MARK2-202
ENSP00000385751
ENST00000402010
Q7KZI7 [Direct mapping]
Serine/threonine-protein kinase MARK2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0000422 [mitophagy]
GO:0001764 [neuron migration]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0008289 [lipid binding]
GO:0010976 [positive regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016328 [lateral plasma membrane]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0030010 [establishment of cell polarity]
GO:0030295 [protein kinase activator activity]
GO:0032147 [activation of protein kinase activity]
GO:0035556 [intracellular signal transduction]
GO:0044822 [poly(A) RNA binding]
GO:0045180 [basal cortex]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0046777 [protein autophosphorylation]
GO:0050321 [tau-protein kinase activity]
GO:0050770 [regulation of axonogenesis]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051646 [mitochondrion localization]
GO:0097427 [microtubule bundle]
Show all
 788 aa
87.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.