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TRNT1

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GENERAL INFORMATION

Gene name

 TRNT1

Gene description

 TRNA nucleotidyl transferase, CCA-adding, 1

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the mitochondria.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (validated)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Validated based on 1 antibody.
HPA036938
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the mitochondria.

Main location

 Mitochondria (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA036938 A-431 Mitochondria
HPA036938 U-2 OS Mitochondria Intensity

GENE INFORMATION

Gene name

 TRNT1 (HGNC Symbol)

Synonyms

 CCA1, CGI-47, MtCCA

Description

 TRNA nucleotidyl transferase, CCA-adding, 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a CCA-adding enzyme which belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. This essential enzyme functions by catalyzing the addition of the conserved nucleotide triplet CCA to the 3' terminus of tRNA molecules. Mutations in this gene result in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Chromosome

 3

Cytoband

 p26.2

Chromosome location (bp)

 3126916 - 3150879

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000072756 (version 83.38)

Entrez gene

 51095

UniProt

 Q96Q11 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96Q11

Antibodypedia

 TRNT1 antibodies

PROTEIN BROWSER
TRNT1-001
TRNT1-002
TRNT1-003
TRNT1-004
TRNT1-007
TRNT1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRNT1-001
ENSP00000251607
ENST00000251607
Q96Q11 [Direct mapping]
CCA tRNA nucleotidyltransferase 1, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0001680 [tRNA 3'-terminal CCA addition]
GO:0003723 [RNA binding]
GO:0004810 [tRNA adenylyltransferase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006396 [RNA processing]
GO:0006626 [protein targeting to mitochondrion]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0016779 [nucleotidyltransferase activity]
GO:0042780 [tRNA 3'-end processing]
GO:0052927 [CTP:tRNA cytidylyltransferase activity]
GO:0052928 [CTP:3'-cytidine-tRNA cytidylyltransferase activity]
GO:0052929 [ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity]
Show all
 434 aa
50.1 kDa 		No 0
TRNT1-002
ENSP00000385745
ENST00000402675
Q96Q11 [Direct mapping]
CCA tRNA nucleotidyltransferase 1, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0001680 [tRNA 3'-terminal CCA addition]
GO:0004810 [tRNA adenylyltransferase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006626 [protein targeting to mitochondrion]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0042780 [tRNA 3'-end processing]
GO:0052927 [CTP:tRNA cytidylyltransferase activity]
GO:0052928 [CTP:3'-cytidine-tRNA cytidylyltransferase activity]
GO:0052929 [ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity]
Show all
 57 aa
6.9 kDa 		No 0
TRNT1-003
ENSP00000342985
ENST00000339437
Q96Q11 [Direct mapping]
CCA tRNA nucleotidyltransferase 1, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0001680 [tRNA 3'-terminal CCA addition]
GO:0004810 [tRNA adenylyltransferase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006626 [protein targeting to mitochondrion]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0042780 [tRNA 3'-end processing]
GO:0052927 [CTP:tRNA cytidylyltransferase activity]
GO:0052928 [CTP:3'-cytidine-tRNA cytidylyltransferase activity]
GO:0052929 [ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity]
Show all
 57 aa
6.9 kDa 		No 0
TRNT1-004
ENSP00000280591
ENST00000280591
Q96Q11 [Direct mapping]
CCA tRNA nucleotidyltransferase 1, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0001680 [tRNA 3'-terminal CCA addition]
GO:0003723 [RNA binding]
GO:0004810 [tRNA adenylyltransferase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006396 [RNA processing]
GO:0006626 [protein targeting to mitochondrion]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0016779 [nucleotidyltransferase activity]
GO:0042780 [tRNA 3'-end processing]
GO:0052927 [CTP:tRNA cytidylyltransferase activity]
GO:0052928 [CTP:3'-cytidine-tRNA cytidylyltransferase activity]
GO:0052929 [ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity]
Show all
 414 aa
47.8 kDa 		No 0
TRNT1-007
ENSP00000400394
ENST00000420393
Q96Q11 [Direct mapping]
CCA tRNA nucleotidyltransferase 1, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0001680 [tRNA 3'-terminal CCA addition]
GO:0004810 [tRNA adenylyltransferase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006626 [protein targeting to mitochondrion]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0042780 [tRNA 3'-end processing]
GO:0052927 [CTP:tRNA cytidylyltransferase activity]
GO:0052928 [CTP:3'-cytidine-tRNA cytidylyltransferase activity]
GO:0052929 [ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity]
Show all
 57 aa
6.9 kDa 		No 0
TRNT1-008
ENSP00000388615
ENST00000413000
C9JRS7 [Direct mapping]
CCA tRNA nucleotidyltransferase 1, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 62 aa
7.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.