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This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007346 [regulation of mitotic cell cycle] GO:0023014 [signal transduction by protein phosphorylation] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032147 [activation of protein kinase activity] GO:0042801 [polo kinase kinase activity] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0046777 [protein autophosphorylation] GO:0070062 [extracellular exosome] GO:0071593 [lymphocyte aggregation] GO:2000401 [regulation of lymphocyte migration]
