Expression of EVC in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Ellis van Creveld protein

Protein class

Disease related genes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA008703	HPA016046

GENE INFORMATION
Gene name	EVC (HGNC Symbol)
Synonyms	DWF-1
Description	Ellis van Creveld protein (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing a leucine zipper and a transmembrane domain. This gene has been implicated in both Ellis-van Creveld syndrome (EvC) and Weyers acrodental dysostosis. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	p16.2
Chromosome location (bp)	5711197 - 5814305
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000072840 (version 83.38)
Entrez gene	2121
UniProt	P57679 (UniProt - Evidence at protein level)
neXtProt	NX_P57679
Antibodypedia	EVC antibodies

PROTEIN BROWSER

EVC-001	EVC-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EVC-001 ENSP00000264956 ENST00000264956	P57679 [Direct mapping] Ellis-van Creveld syndrome protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0001501 [skeletal system development] GO:0003416 [endochondral bone growth] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005929 [cilium] GO:0007224 [smoothened signaling pathway] GO:0007517 [muscle organ development] GO:0016021 [integral component of membrane] GO:0036064 [ciliary basal body] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0051216 [cartilage development] GO:0060170 [ciliary membrane] Show all	992 aa 112 kDa	No	1
EVC-002 ENSP00000426774 ENST00000509451	E9PCN4 [Direct mapping] Ellis-van Creveld syndrome protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0007224 [smoothened signaling pathway] GO:0016021 [integral component of membrane] Show all	535 aa 60 kDa	No	1