Cell atlas - KDM5A - The Human Protein Atlas

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KDM5A

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear bodies

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	KDM5A
Gene description	Lysine (K)-specific demethylase 5A
Protein class	Cancer-related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear bodies. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (approved)
Additional location	In addition localized to the Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA006201
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear bodies. In addition localized to the cytosol.

Main location

Nuclear bodies (approved)

Additional location

Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA006201	A-431	Nuclear bodies
	HPA006201	A-431	Cytosol
	HPA006201	U-2 OS	Nuclear bodies
	HPA006201	U-2 OS	Cytosol
	HPA006201	U-251 MG	Nuclear bodies

GENE INFORMATION
Gene name	KDM5A (HGNC Symbol)
Synonyms	JARID1A, RBBP2
Description	Lysine (K)-specific demethylase 5A (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013]
Chromosome	12
Cytoband	p13.33
Chromosome location (bp)	280129 - 389454
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000073614 (version 83.38)
Entrez gene	5927
UniProt	P29375 (UniProt - Evidence at protein level)
neXtProt	NX_P29375
Antibodypedia	KDM5A antibodies

PROTEIN BROWSER

KDM5A-001	KDM5A-009	KDM5A-010	KDM5A-011	KDM5A-012	KDM5A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KDM5A-001 ENSP00000382688 ENST00000399788	P29375 [Direct mapping] Lysine-specific demethylase 5A Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006325 [chromatin organization] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0008270 [zinc ion binding] GO:0008584 [male gonad development] GO:0016568 [chromatin modification] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0019907 [cyclin-dependent protein kinase activating kinase holoenzyme complex] GO:0031490 [chromatin DNA binding] GO:0032922 [circadian regulation of gene expression] GO:0032993 [protein-DNA complex] GO:0034720 [histone H3-K4 demethylation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0055114 [oxidation-reduction process] GO:1901726 [negative regulation of histone deacetylase activity] Show all	1690 aa 192.1 kDa	No	0
KDM5A-009 ENSP00000444251 ENST00000543507	F5GZR8 [Direct mapping] Lysine-specific demethylase 5A Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] Show all	131 aa 15 kDa	No	0
KDM5A-010 ENSP00000438203 ENST00000536014	F5H322 [Direct mapping] Lysine-specific demethylase 5A Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] Show all	123 aa 14.4 kDa	No	0
KDM5A-011 ENSP00000443854 ENST00000535014	F5GZ99 [Direct mapping] Lysine-specific demethylase 5A Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] Show all	126 aa 14.1 kDa	No	0
KDM5A-012 ENSP00000440622 ENST00000544760	E7EV89 [Direct mapping] Lysine-specific demethylase 5A Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0055114 [oxidation-reduction process] Show all	715 aa 81.5 kDa	No	0
KDM5A-201 ENSP00000372265 ENST00000382815	F5H1F7 [Direct mapping] Lysine-specific demethylase 5A Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0055114 [oxidation-reduction process] Show all	1722 aa 195.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.