Tissue expression of ADAM11 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ADAM11
Gene description	ADAM metallopeptidase domain 11
Protein class	Enzymes Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Tissue enhanced (cerebellum, cerebral cortex)
FANTOM5:	Group enriched (cerebellum, hippocampus, brain)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum, cerebral cortex)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebellum, hippocampus, brain)

GENE INFORMATION
Gene name	ADAM11 (HGNC Symbol)
Synonyms	MDC
Description	ADAM metallopeptidase domain 11 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. [provided by RefSeq, Dec 2014]
Chromosome	17
Cytoband	q21.31
Chromosome location (bp)	44759031 - 44781846
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000073670 (version 83.38)
Entrez gene	4185
UniProt	O75078 (UniProt - Evidence at transcript level)
neXtProt	NX_O75078
Antibodypedia	ADAM11 antibodies

PROTEIN BROWSER

ADAM11-001	ADAM11-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAM11-001 ENSP00000200557 ENST00000200557	O75078 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 11 Show all	Enzymes Peptidases Metallopeptidases Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007229 [integrin-mediated signaling pathway] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0031012 [extracellular matrix] Show all	769 aa 83.4 kDa	Yes	1
ADAM11-004 ENSP00000443773 ENST00000535346	B4DKD2 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 11; cDNA FLJ60626, highly similar to ADAM 11 (A disintegrin and metalloproteinase domain 11) Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0007229 [integrin-mediated signaling pathway] GO:0016021 [integral component of membrane] Show all	569 aa 61.6 kDa	No	1