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FERMT2

GENERAL INFORMATION

Gene name

 FERMT2

Gene description

 Fermitin family member 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA040505
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FERMT2 (HGNC Symbol)

Synonyms

 KIND2, mig-2, PLEKHC1, UNC112B

Description

 Fermitin family member 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 14

Cytoband

 q22.1

Chromosome location (bp)

 52857268 - 52952435

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000073712 (version 83.38)

Entrez gene

 10979

UniProt

 Q96AC1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96AC1

Antibodypedia

 FERMT2 antibodies

PROTEIN BROWSER
«
FERMT2-001
FERMT2-002
FERMT2-003
FERMT2-004
FERMT2-005
FERMT2-007
FERMT2-009
FERMT2-010
FERMT2-012
FERMT2-014
FERMT2-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FERMT2-001
ENSP00000340391
ENST00000341590
Q96AC1 [Direct mapping]
Fermitin family homolog 2
A0A024R687 [Target identity:100%; Query identity:100%]
Pleckstrin homology domain containing, family C (With FERM domain) member 1, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007160 [cell-matrix adhesion]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0016055 [Wnt signaling pathway]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031258 [lamellipodium membrane]
GO:0031674 [I band]
GO:0033622 [integrin activation]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0048041 [focal adhesion assembly]
GO:0072657 [protein localization to membrane]
Show all
 680 aa
77.9 kDa 		No 0
FERMT2-002
ENSP00000378993
ENST00000395631
Q96AC1 [Direct mapping]
Fermitin family homolog 2
A0A024R687 [Target identity:100%; Query identity:100%]
Pleckstrin homology domain containing, family C (With FERM domain) member 1, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007160 [cell-matrix adhesion]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0016055 [Wnt signaling pathway]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031258 [lamellipodium membrane]
GO:0031674 [I band]
GO:0033622 [integrin activation]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0048041 [focal adhesion assembly]
GO:0072657 [protein localization to membrane]
Show all
 680 aa
77.9 kDa 		No 0
FERMT2-003
ENSP00000451084
ENST00000553373
Q96AC1 [Direct mapping]
Fermitin family homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007160 [cell-matrix adhesion]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0016055 [Wnt signaling pathway]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031258 [lamellipodium membrane]
GO:0031674 [I band]
GO:0033622 [integrin activation]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0048041 [focal adhesion assembly]
GO:0072657 [protein localization to membrane]
Show all
 687 aa
78.7 kDa 		No 0
FERMT2-004
ENSP00000382243
ENST00000399304
Q96AC1 [Direct mapping]
Fermitin family homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007160 [cell-matrix adhesion]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0016055 [Wnt signaling pathway]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031258 [lamellipodium membrane]
GO:0031674 [I band]
GO:0033622 [integrin activation]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0048041 [focal adhesion assembly]
GO:0072657 [protein localization to membrane]
Show all
 633 aa
72.4 kDa 		No 0
FERMT2-005
ENSP00000451134
ENST00000553663
H0YJB6 [Direct mapping]
Fermitin family homolog 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005856 [cytoskeleton]
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 133 aa
15.5 kDa 		No 0
FERMT2-007
ENSP00000450741
ENST00000554152
H0YJ34 [Direct mapping]
Fermitin family homolog 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005925 [focal adhesion]
Show all
 640 aa
73.4 kDa 		No 0
FERMT2-009
ENSP00000451268
ENST00000554288
G3V3J0 [Direct mapping]
Fermitin family homolog 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 155 aa
17.1 kDa 		No 0
FERMT2-010
ENSP00000452472
ENST00000555692
G3V5R2 [Direct mapping]
Fermitin family homolog 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 133 aa
15.8 kDa 		No 0
FERMT2-012
ENSP00000450506
ENST00000554712
G3V281 [Direct mapping]
Fermitin family homolog 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 153 aa
17.9 kDa 		No 0
FERMT2-014
ENSP00000489609
ENST00000635305
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 545 aa
61.8 kDa 		No 0
FERMT2-201
ENSP00000342858
ENST00000343279
Q96AC1 [Direct mapping]
Fermitin family homolog 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0005515 [protein binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007160 [cell-matrix adhesion]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0016055 [Wnt signaling pathway]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031258 [lamellipodium membrane]
GO:0031674 [I band]
GO:0031941 [filamentous actin]
GO:0033622 [integrin activation]
GO:0034329 [cell junction assembly]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0048041 [focal adhesion assembly]
GO:0072657 [protein localization to membrane]
Show all
 687 aa
78.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.