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DHRS9

GENERAL INFORMATION

Gene name

 DHRS9

Gene description

 Dehydrogenase/reductase (SDR family) member 9

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (colon, rectum)
GTEx:Tissue enhanced (colon)
FANTOM5:Tissue enhanced (adipose tissue)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA036491 , HPA036667
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, rectum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue)

GENE INFORMATION

Gene name

 DHRS9 (HGNC Symbol)

Synonyms

 3alpha-HSD, RDH15, RDHL, RETSDR8, SDR9C4

Description

 Dehydrogenase/reductase (SDR family) member 9 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 169064789 - 169096167

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000073737 (version 83.38)

Entrez gene

 10170

UniProt

 Q9BPW9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BPW9

Antibodypedia

 DHRS9 antibodies

PROTEIN BROWSER
DHRS9-001
DHRS9-002
DHRS9-004
DHRS9-005
DHRS9-006
DHRS9-008
DHRS9-201
DHRS9-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DHRS9-001
ENSP00000350154
ENST00000357546
Q9BPW9 [Direct mapping]
Dehydrogenase/reductase SDR family member 9
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0004745 [retinol dehydrogenase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0008152 [metabolic process]
GO:0008209 [androgen metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016854 [racemase and epimerase activity]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030855 [epithelial cell differentiation]
GO:0042448 [progesterone metabolic process]
GO:0042572 [retinol metabolic process]
GO:0042904 [9-cis-retinoic acid biosynthetic process]
GO:0047035 [testosterone dehydrogenase (NAD+) activity]
GO:0055114 [oxidation-reduction process]
Show all
 319 aa
35.2 kDa 		Yes 0
DHRS9-002
ENSP00000473337
ENST00000602501
Q9BPW9 [Direct mapping]
Dehydrogenase/reductase SDR family member 9
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0004745 [retinol dehydrogenase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0008152 [metabolic process]
GO:0008209 [androgen metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016854 [racemase and epimerase activity]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030855 [epithelial cell differentiation]
GO:0042448 [progesterone metabolic process]
GO:0042572 [retinol metabolic process]
GO:0042904 [9-cis-retinoic acid biosynthetic process]
GO:0047035 [testosterone dehydrogenase (NAD+) activity]
GO:0055114 [oxidation-reduction process]
Show all
 319 aa
35.2 kDa 		Yes 0
DHRS9-004
ENSP00000407167
ENST00000436483
Q9BPW9 [Direct mapping]
Dehydrogenase/reductase SDR family member 9
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0004745 [retinol dehydrogenase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0008152 [metabolic process]
GO:0008209 [androgen metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016854 [racemase and epimerase activity]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030855 [epithelial cell differentiation]
GO:0042448 [progesterone metabolic process]
GO:0042572 [retinol metabolic process]
GO:0042904 [9-cis-retinoic acid biosynthetic process]
GO:0047035 [testosterone dehydrogenase (NAD+) activity]
GO:0055114 [oxidation-reduction process]
Show all
 319 aa
35.2 kDa 		Yes 0
DHRS9-005
ENSP00000388564
ENST00000428522
Q9BPW9 [Direct mapping]
Dehydrogenase/reductase SDR family member 9
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0004745 [retinol dehydrogenase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0008152 [metabolic process]
GO:0008209 [androgen metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016854 [racemase and epimerase activity]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030855 [epithelial cell differentiation]
GO:0042448 [progesterone metabolic process]
GO:0042572 [retinol metabolic process]
GO:0042904 [9-cis-retinoic acid biosynthetic process]
GO:0047035 [testosterone dehydrogenase (NAD+) activity]
GO:0055114 [oxidation-reduction process]
Show all
 319 aa
35.2 kDa 		Yes 0
DHRS9-006
ENSP00000391214
ENST00000450153
C9J430 [Direct mapping]
Dehydrogenase/reductase SDR family member 9
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 66 aa
7.3 kDa 		Yes 0
DHRS9-008
ENSP00000388066
ENST00000421653
Q9BPW9 [Direct mapping]
Dehydrogenase/reductase SDR family member 9
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0004745 [retinol dehydrogenase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0008209 [androgen metabolic process]
GO:0016854 [racemase and epimerase activity]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030855 [epithelial cell differentiation]
GO:0042448 [progesterone metabolic process]
GO:0042572 [retinol metabolic process]
GO:0042904 [9-cis-retinoic acid biosynthetic process]
GO:0047035 [testosterone dehydrogenase (NAD+) activity]
GO:0055114 [oxidation-reduction process]
Show all
 172 aa
18.9 kDa 		No 0
DHRS9-201
ENSP00000407747
ENST00000412271
Q9BPW9 [Direct mapping]
Dehydrogenase/reductase SDR family member 9
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0004745 [retinol dehydrogenase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0008152 [metabolic process]
GO:0008209 [androgen metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016854 [racemase and epimerase activity]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030855 [epithelial cell differentiation]
GO:0042448 [progesterone metabolic process]
GO:0042572 [retinol metabolic process]
GO:0042904 [9-cis-retinoic acid biosynthetic process]
GO:0047035 [testosterone dehydrogenase (NAD+) activity]
GO:0055114 [oxidation-reduction process]
Show all
 319 aa
35.2 kDa 		Yes 0
DHRS9-202
ENSP00000389241
ENST00000432060
Q9BPW9 [Direct mapping]
Dehydrogenase/reductase SDR family member 9
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002138 [retinoic acid biosynthetic process]
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0004745 [retinol dehydrogenase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0008152 [metabolic process]
GO:0008209 [androgen metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016854 [racemase and epimerase activity]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030855 [epithelial cell differentiation]
GO:0042448 [progesterone metabolic process]
GO:0042572 [retinol metabolic process]
GO:0042904 [9-cis-retinoic acid biosynthetic process]
GO:0047035 [testosterone dehydrogenase (NAD+) activity]
GO:0055114 [oxidation-reduction process]
Show all
 379 aa
41.9 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.