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Cervical, endometrial, urothelial, pancreatic, lung, gastric cancer and malignant gliomas showed moderate to strong cytoplasmic positivity. Malignant lymphomas, testis and renal cancers were generally negative.
Strong to moderate cytoplasmic and occasional membranous positivity was observed in colorectal, prostate, cervical, endometrial, urothelial, pancreatic and liver cancers. Most other remaining tumors were negative.
GENE INFORMATION
Gene name
PTGS2 (HGNC Symbol)
Synonyms
COX2
Description
Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (HGNC Symbol)
Entrez gene summary
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]