We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Strong nuclear staining was observed in Hodkins disease while a few other lymphomas showed weak to moderate nuclear positivity. Cancer cells in general displayed weakly cytoplasmic staining or were negative.
Hodgkins lymphomas displayed strong nuclear immunoreactivity. Remaining cancer cells were negative.
GENE INFORMATION
Gene name
TBX21 (HGNC Symbol)
Synonyms
T-bet, TBLYM
Description
T-box 21 (HGNC Symbol)
Entrez gene summary
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Transcription factors Immunoglobulin fold Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0009615 [response to virus] GO:0030217 [T cell differentiation] GO:0043025 [neuronal cell body] GO:0044212 [transcription regulatory region DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048304 [positive regulation of isotype switching to IgG isotypes] GO:0050776 [regulation of immune response] GO:0071310 [cellular response to organic substance] GO:0072676 [lymphocyte migration]
