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CLASP1

GENERAL INFORMATION

Gene name

 CLASP1

Gene description

 Cytoplasmic linker associated protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissue types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA065219
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CLASP1 (HGNC Symbol)

Synonyms

 KIAA0622, MAST1

Description

 Cytoplasmic linker associated protein 1 (HGNC Symbol)

Entrez gene summary

 CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]

Chromosome

 2

Cytoband

Chromosome location (bp)

 121337776 - 121649587

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000074054 (version 83.38)

Entrez gene

 23332

UniProt

 Q7Z460 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z460

Antibodypedia

 CLASP1 antibodies

PROTEIN BROWSER
CLASP1-001
CLASP1-012
CLASP1-013
CLASP1-016
CLASP1-201
CLASP1-202
CLASP1-203
CLASP1-204

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLASP1-001
ENSP00000386442
ENST00000409078
Q7Z460 [Direct mapping]
CLIP-associating protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0001578 [microtubule bundle formation]
GO:0002162 [dystroglycan binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005828 [kinetochore microtubule]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006903 [vesicle targeting]
GO:0006996 [organelle organization]
GO:0007020 [microtubule nucleation]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007030 [Golgi organization]
GO:0007052 [mitotic spindle organization]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0010458 [exit from mitosis]
GO:0010470 [regulation of gastrulation]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010717 [regulation of epithelial to mesenchymal transition]
GO:0016020 [membrane]
GO:0030953 [astral microtubule organization]
GO:0030981 [cortical microtubule cytoskeleton]
GO:0031023 [microtubule organizing center organization]
GO:0031111 [negative regulation of microtubule polymerization or depolymerization]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031592 [centrosomal corona]
GO:0034453 [microtubule anchoring]
GO:0035371 [microtubule plus-end]
GO:0040001 [establishment of mitotic spindle localization]
GO:0043515 [kinetochore binding]
GO:0045180 [basal cortex]
GO:0045921 [positive regulation of exocytosis]
GO:0051010 [microtubule plus-end binding]
GO:0051294 [establishment of spindle orientation]
GO:0051301 [cell division]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051893 [regulation of focal adhesion assembly]
GO:0070062 [extracellular exosome]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0090091 [positive regulation of extracellular matrix disassembly]
GO:0090162 [establishment of epithelial cell polarity]
GO:0090307 [mitotic spindle assembly]
GO:1903690 [negative regulation of wound healing, spreading of epidermal cells]
GO:1904261 [positive regulation of basement membrane assembly involved in embryonic body morphogenesis]
Show all
 1471 aa
162.1 kDa 		No 0
CLASP1-012
ENSP00000392886
ENST00000418989
C9J151 [Direct mapping]
CLIP-associating protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 150 aa
16.5 kDa 		No 0
CLASP1-013
ENSP00000402101
ENST00000449975
C9JP76 [Direct mapping]
CLIP-associating protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 110 aa
12 kDa 		No 0
CLASP1-016
ENSP00000400562
ENST00000452274
H0Y5T1 [Direct mapping]
CLIP-associating protein 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005828 [kinetochore microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0043515 [kinetochore binding]
GO:0051010 [microtubule plus-end binding]
Show all
 1275 aa
139.9 kDa 		No 0
CLASP1-201
ENSP00000263710
ENST00000263710
Q7Z460 [Direct mapping]
CLIP-associating protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0001578 [microtubule bundle formation]
GO:0002162 [dystroglycan binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005828 [kinetochore microtubule]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006903 [vesicle targeting]
GO:0006996 [organelle organization]
GO:0007020 [microtubule nucleation]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007030 [Golgi organization]
GO:0007052 [mitotic spindle organization]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0010458 [exit from mitosis]
GO:0010470 [regulation of gastrulation]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010717 [regulation of epithelial to mesenchymal transition]
GO:0016020 [membrane]
GO:0030953 [astral microtubule organization]
GO:0030981 [cortical microtubule cytoskeleton]
GO:0031023 [microtubule organizing center organization]
GO:0031111 [negative regulation of microtubule polymerization or depolymerization]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031592 [centrosomal corona]
GO:0034453 [microtubule anchoring]
GO:0035371 [microtubule plus-end]
GO:0040001 [establishment of mitotic spindle localization]
GO:0043515 [kinetochore binding]
GO:0045180 [basal cortex]
GO:0045921 [positive regulation of exocytosis]
GO:0051010 [microtubule plus-end binding]
GO:0051294 [establishment of spindle orientation]
GO:0051301 [cell division]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051893 [regulation of focal adhesion assembly]
GO:0070062 [extracellular exosome]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0090091 [positive regulation of extracellular matrix disassembly]
GO:0090162 [establishment of epithelial cell polarity]
GO:0090307 [mitotic spindle assembly]
GO:1903690 [negative regulation of wound healing, spreading of epidermal cells]
GO:1904261 [positive regulation of basement membrane assembly involved in embryonic body morphogenesis]
Show all
 1538 aa
169.4 kDa 		No 0
CLASP1-202
ENSP00000380717
ENST00000397587
Q7Z460 [Direct mapping]
CLIP-associating protein 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0001578 [microtubule bundle formation]
GO:0002162 [dystroglycan binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005828 [kinetochore microtubule]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006903 [vesicle targeting]
GO:0006996 [organelle organization]
GO:0007020 [microtubule nucleation]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007030 [Golgi organization]
GO:0007052 [mitotic spindle organization]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0010458 [exit from mitosis]
GO:0010470 [regulation of gastrulation]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010717 [regulation of epithelial to mesenchymal transition]
GO:0016020 [membrane]
GO:0030953 [astral microtubule organization]
GO:0030981 [cortical microtubule cytoskeleton]
GO:0031023 [microtubule organizing center organization]
GO:0031111 [negative regulation of microtubule polymerization or depolymerization]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031592 [centrosomal corona]
GO:0034453 [microtubule anchoring]
GO:0035371 [microtubule plus-end]
GO:0040001 [establishment of mitotic spindle localization]
GO:0043515 [kinetochore binding]
GO:0045180 [basal cortex]
GO:0045921 [positive regulation of exocytosis]
GO:0051010 [microtubule plus-end binding]
GO:0051294 [establishment of spindle orientation]
GO:0051301 [cell division]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051893 [regulation of focal adhesion assembly]
GO:0070062 [extracellular exosome]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0090091 [positive regulation of extracellular matrix disassembly]
GO:0090162 [establishment of epithelial cell polarity]
GO:0090307 [mitotic spindle assembly]
GO:1903690 [negative regulation of wound healing, spreading of epidermal cells]
GO:1904261 [positive regulation of basement membrane assembly involved in embryonic body morphogenesis]
Show all
 1479 aa
162.9 kDa 		No 0
CLASP1-203
ENSP00000389372
ENST00000455322
F8WA11 [Direct mapping]
CLIP-associating protein 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005828 [kinetochore microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0043515 [kinetochore binding]
GO:0051010 [microtubule plus-end binding]
Show all
 1478 aa
162.8 kDa 		No 0
CLASP1-204
ENSP00000441625
ENST00000541377
Q7Z460 [Direct mapping]
CLIP-associating protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0001578 [microtubule bundle formation]
GO:0002162 [dystroglycan binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005828 [kinetochore microtubule]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006903 [vesicle targeting]
GO:0006996 [organelle organization]
GO:0007020 [microtubule nucleation]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007030 [Golgi organization]
GO:0007052 [mitotic spindle organization]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0010458 [exit from mitosis]
GO:0010470 [regulation of gastrulation]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010717 [regulation of epithelial to mesenchymal transition]
GO:0016020 [membrane]
GO:0030953 [astral microtubule organization]
GO:0030981 [cortical microtubule cytoskeleton]
GO:0031023 [microtubule organizing center organization]
GO:0031111 [negative regulation of microtubule polymerization or depolymerization]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031592 [centrosomal corona]
GO:0034453 [microtubule anchoring]
GO:0035371 [microtubule plus-end]
GO:0040001 [establishment of mitotic spindle localization]
GO:0043515 [kinetochore binding]
GO:0045180 [basal cortex]
GO:0045921 [positive regulation of exocytosis]
GO:0051010 [microtubule plus-end binding]
GO:0051294 [establishment of spindle orientation]
GO:0051301 [cell division]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051893 [regulation of focal adhesion assembly]
GO:0070062 [extracellular exosome]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0090091 [positive regulation of extracellular matrix disassembly]
GO:0090162 [establishment of epithelial cell polarity]
GO:0090307 [mitotic spindle assembly]
GO:1903690 [negative regulation of wound healing, spreading of epidermal cells]
GO:1904261 [positive regulation of basement membrane assembly involved in embryonic body morphogenesis]
Show all
 1477 aa
163.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.