Expression of MRPS34 in cancer - Summary

CANCER ATLAS

Gene description

Mitochondrial ribosomal protein S34

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042112

GENE INFORMATION
Gene name	MRPS34 (HGNC Symbol)
Synonyms	MGC2616, MRP-S12
Description	Mitochondrial ribosomal protein S34 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	1771890 - 1773155
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000074071 (version 83.38)
Entrez gene	65993
UniProt	P82930 (UniProt - Evidence at protein level)
neXtProt	NX_P82930
Antibodypedia	MRPS34 antibodies

PROTEIN BROWSER

MRPS34-001	MRPS34-002	MRPS34-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPS34-001 ENSP00000380531 ENST00000397375	P82930 [Direct mapping] 28S ribosomal protein S34, mitochondrial Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005840 [ribosome] GO:0006996 [organelle organization] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	218 aa 25.7 kDa	No	0
MRPS34-002 ENSP00000177742 ENST00000177742	C9JJ19 [Direct mapping] 28S ribosomal protein S34, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0032543 [mitochondrial translation] Show all	225 aa 26.3 kDa	No	0
MRPS34-201 ENSP00000479049 ENST00000613089	A0A087WUZ8 [Direct mapping] 28S ribosomal protein S34, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		176 aa 20.7 kDa	No	0