Cell atlas - SLC24A1 - The Human Protein Atlas

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SLC24A1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubules

Human cell
	Microtubules

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GENERAL INFORMATION
Gene name	SLC24A1
Gene description	Solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the microtubules.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA039370
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the microtubules.

Main location

Microtubules (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA039370	A-431	Microtubules
	HPA039370	U-2 OS	Microtubules
	HPA039370	U-251 MG	Microtubules

GENE INFORMATION
Gene name	SLC24A1 (HGNC Symbol)
Synonyms	CSNB1D, HsT17412, KIAA0702, NCKX, NCKX1, RODX
Description	Solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. The encoded protein plays an important role in sodium/calcium exchange in retinal rod and cone photoreceptors by mediating the extrusion of one calcium ion and one potassium ion in exchange for four sodium ions. Mutations in this gene may play a role in congenital stationary night blindness. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Chromosome	15
Cytoband	q22.31
Chromosome location (bp)	65611366 - 65660995
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000074621 (version 83.38)
Entrez gene	9187
UniProt	O60721 (UniProt - Evidence at protein level)
neXtProt	NX_O60721
Antibodypedia	SLC24A1 antibodies

PROTEIN BROWSER

SLC24A1-001	SLC24A1-002	SLC24A1-004	SLC24A1-005	SLC24A1-007	SLC24A1-011	SLC24A1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC24A1-001 ENSP00000261892 ENST00000261892	O60721 [Direct mapping] Sodium/potassium/calcium exchanger 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007601 [visual perception] GO:0007603 [phototransduction, visible light] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0009642 [response to light intensity] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016056 [rhodopsin mediated signaling pathway] GO:0019867 [outer membrane] GO:0030955 [potassium ion binding] GO:0031402 [sodium ion binding] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	1099 aa 121.4 kDa	No	8
SLC24A1-002 ENSP00000439693 ENST00000537259	F5H127 [Direct mapping] Sodium/potassium/calcium exchanger 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0006816 [calcium ion transport] GO:0007601 [visual perception] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	1012 aa 111.6 kDa	No	6
SLC24A1-004 ENSP00000381991 ENST00000399033	O60721 [Direct mapping] Sodium/potassium/calcium exchanger 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005262 [calcium channel activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007601 [visual perception] GO:0007603 [phototransduction, visible light] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0009642 [response to light intensity] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016056 [rhodopsin mediated signaling pathway] GO:0019867 [outer membrane] GO:0030955 [potassium ion binding] GO:0031402 [sodium ion binding] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	1069 aa 117.6 kDa	No	9
SLC24A1-005 ENSP00000439190 ENST00000546330	O60721 [Direct mapping] Sodium/potassium/calcium exchanger 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005262 [calcium channel activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007601 [visual perception] GO:0007603 [phototransduction, visible light] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0009642 [response to light intensity] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016056 [rhodopsin mediated signaling pathway] GO:0019867 [outer membrane] GO:0030955 [potassium ion binding] GO:0031402 [sodium ion binding] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	1081 aa 119.5 kDa	No	8
SLC24A1-007 ENSP00000445163 ENST00000544319	F5H483 [Direct mapping] Sodium/potassium/calcium exchanger 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0006816 [calcium ion transport] GO:0007601 [visual perception] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	985 aa 109.1 kDa	No	9
SLC24A1-011 ENSP00000445577 ENST00000505666	H0YH06 [Direct mapping] Sodium/potassium/calcium exchanger 1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all		56 aa 5.7 kDa	No	0
SLC24A1-201 ENSP00000341837 ENST00000339868	O60721 [Direct mapping] Sodium/potassium/calcium exchanger 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005262 [calcium channel activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007601 [visual perception] GO:0007603 [phototransduction, visible light] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0009642 [response to light intensity] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016056 [rhodopsin mediated signaling pathway] GO:0019867 [outer membrane] GO:0030955 [potassium ion binding] GO:0031402 [sodium ion binding] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	1069 aa 117.6 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.