Expression of HACD3 in cancer - Summary - The Human Protein Atlas

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HACD3

TISSUE

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CELL

CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

CANCER ATLAS

Gene description

3-hydroxyacyl-CoA dehydratase 3

Protein class

Enzymes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA014837

GENE INFORMATION
Gene name	HACD3 (HGNC Symbol)
Synonyms	B-ind1, HSPC121, PTPLAD1
Description	3-hydroxyacyl-CoA dehydratase 3 (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q22.31
Chromosome location (bp)	65530418 - 65578352
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000074696 (version 83.38)
Entrez gene	51495
UniProt	Q9P035 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P035
Antibodypedia	HACD3 antibodies

PROTEIN BROWSER

HACD3-001	HACD3-003	HACD3-004	HACD3-005	HACD3-006	HACD3-007	HACD3-008	HACD3-009	HACD3-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HACD3-001 ENSP00000261875 ENST00000261875	Q9P035 [Direct mapping] Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 Show all	Enzymes ENZYME proteins Lyases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005925 [focal adhesion] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007254 [JNK cascade] GO:0007257 [activation of JUN kinase activity] GO:0007264 [small GTPase mediated signal transduction] GO:0007266 [Rho protein signal transduction] GO:0016021 [integral component of membrane] GO:0016601 [Rac protein signal transduction] GO:0018812 [3-hydroxyacyl-CoA dehydratase activity] GO:0019899 [enzyme binding] GO:0030497 [fatty acid elongation] GO:0042761 [very long-chain fatty acid biosynthetic process] GO:0043547 [positive regulation of GTPase activity] GO:0045070 [positive regulation of viral genome replication] GO:0046726 [positive regulation by virus of viral protein levels in host cell] Show all	362 aa 43.2 kDa	No	6
HACD3-003 ENSP00000455686 ENST00000562901	H3BRL8 [Direct mapping] Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	245 aa 29.2 kDa	No	6
HACD3-004 ENSP00000456568 ENST00000565299	H3BS72 [Direct mapping] Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	400 aa 47.1 kDa	No	6
HACD3-005 ENSP00000455530 ENST00000568793	H3BPZ1 [Direct mapping] Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	337 aa 40.1 kDa	No	6
HACD3-006 ENSP00000456300 ENST00000566074	H3BRL8 [Direct mapping] Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	245 aa 29.2 kDa	No	6
HACD3-007 ENSP00000455587 ENST00000566511	H3BRL8 [Direct mapping] Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	245 aa 29.2 kDa	No	6
HACD3-008 ENSP00000454873 ENST00000569894	H3BRL8 [Direct mapping] Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	245 aa 29.2 kDa	No	6
HACD3-009 ENSP00000454610 ENST00000562832	H3BMZ1 [Direct mapping] Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	139 aa 16.2 kDa	No	4
HACD3-011 ENSP00000392491 ENST00000442729	Q9P035 [Direct mapping] Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 Show all	Enzymes ENZYME proteins Lyases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005925 [focal adhesion] GO:0007257 [activation of JUN kinase activity] GO:0007264 [small GTPase mediated signal transduction] GO:0016021 [integral component of membrane] GO:0016601 [Rac protein signal transduction] GO:0018812 [3-hydroxyacyl-CoA dehydratase activity] GO:0019899 [enzyme binding] GO:0030497 [fatty acid elongation] GO:0042761 [very long-chain fatty acid biosynthetic process] GO:0043547 [positive regulation of GTPase activity] GO:0045070 [positive regulation of viral genome replication] GO:0046726 [positive regulation by virus of viral protein levels in host cell] Show all	307 aa 36.4 kDa	No	6

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.