Expression of ENO1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Enolase 1, (alpha)

Protein class

Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Renal cancer

STAINING SUMMARY

CAB018614	CAB069394

GENE INFORMATION
Gene name	ENO1 (HGNC Symbol)
Synonyms	ENO1L1, MBP-1, MPB1, PPH
Description	Enolase 1, (alpha) (HGNC Symbol)
Entrez gene summary	This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]
Chromosome	1
Cytoband	p36.23
Chromosome location (bp)	8861002 - 8879249
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000074800 (version 83.38)
Entrez gene	2023
UniProt	P06733 (UniProt - Evidence at protein level)
neXtProt	NX_P06733
Antibodypedia	ENO1 antibodies

PROTEIN BROWSER

ENO1-001	ENO1-004	ENO1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ENO1-001 ENSP00000234590 ENST00000234590	P06733 [Direct mapping] Alpha-enolase A0A024R4F1 [Target identity:100%; Query identity:100%] Enolase 1, (Alpha), isoform CRA_a Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000015 [phosphopyruvate hydratase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0004634 [phosphopyruvate hydratase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006096 [glycolytic process] GO:0006351 [transcription, DNA-templated] GO:0009615 [response to virus] GO:0016020 [membrane] GO:0030308 [negative regulation of cell growth] GO:0031430 [M band] GO:0044281 [small molecule metabolic process] GO:0044822 [poly(A) RNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0051020 [GTPase binding] GO:0061621 [canonical glycolysis] GO:0070062 [extracellular exosome] Show all	434 aa 47.2 kDa	No	0
ENO1-004 ENSP00000466406 ENST00000497492	K7EM90 [Direct mapping] Enolase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000015 [phosphopyruvate hydratase complex] GO:0000287 [magnesium ion binding] GO:0004634 [phosphopyruvate hydratase activity] GO:0006096 [glycolytic process] Show all	195 aa 21 kDa	No	0
ENO1-008 ENSP00000468392 ENST00000489867	K7ERS8 [Direct mapping] Alpha-enolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		18 aa 2.1 kDa	No	0