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Potassium channel, voltage gated KQT-like subfamily Q, member 2
Protein class
Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels
Few melanomas, thyroid cancers along with rare cases of head neck cancer, renal, stomach and pancreatic cancers showed weak to moderate nuclear positivity. Other cancer tissues were negative.
Few cases of gliomas showed moderate cytoplasmic staining. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
KCNQ2 (HGNC Symbol)
Synonyms
BFNC, EBN, EBN1, ENB1, HNSPC, KCNA11, Kv7.2
Description
Potassium channel, voltage gated KQT-like subfamily Q, member 2 (HGNC Symbol)
Entrez gene summary
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
