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CACNG4

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GENERAL INFORMATION

Gene name

 CACNG4

Gene description

 Calcium channel, voltage-dependent, gamma subunit 4

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol.

RNA cell category

 Cell line enriched (SH-SY5Y)

Protein evidence

 Evidence at transcript level

Main location

 Localized to the Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA065370
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SH-SY5Y)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol.

Main location

 Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA065370 SH-SY5Y Cytosol
HPA065370 U-2 OS No staining    

GENE INFORMATION

Gene name

 CACNG4 (HGNC Symbol)

Synonyms

 MGC11138, MGC24983

Description

 Calcium channel, voltage-dependent, gamma subunit 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010]

Chromosome

 17

Cytoband

 q24.2

Chromosome location (bp)

 66964910 - 67033398

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000075461 (version 83.38)

Entrez gene

 27092

UniProt

 Q9UBN1 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UBN1

Antibodypedia

 CACNG4 antibodies

PROTEIN BROWSER
CACNG4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CACNG4-001
ENSP00000262138
ENST00000262138
Q9UBN1 [Direct mapping]
Voltage-dependent calcium channel gamma-4 subunit
A0A024R8J8 [Target identity:100%; Query identity:100%]
Voltage-dependent calcium channel gamma subunit
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Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
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GO:0005245 [voltage-gated calcium channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0007268 [synaptic transmission]
GO:0016021 [integral component of membrane]
GO:0016247 [channel regulator activity]
GO:0019226 [transmission of nerve impulse]
GO:0030666 [endocytic vesicle membrane]
GO:0032281 [AMPA glutamate receptor complex]
GO:0051899 [membrane depolarization]
GO:0070588 [calcium ion transmembrane transport]
GO:2000311 [regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity]
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 327 aa
36.6 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.