Cell atlas - FRYL - The Human Protein Atlas

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FRYL

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Cytokinetic bridge
	Cytosol
	Microtubules

Human cell
	Cytosol
	Microtubules

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GENERAL INFORMATION
Gene name	FRYL
Gene description	FRY-like
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the microtubules & cytokinetic bridge.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Microtubules (approved), Cytokinetic bridge (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA031106 , HPA031107
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the microtubules & cytokinetic bridge.

Main location

Cytosol (approved)

Additional location

Microtubules (approved), Cytokinetic bridge (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
HPA031106	A-431	Cytosol
HPA031106	U-2 OS	Cytosol
HPA031107	A-431	Cytosol
HPA031107	U-2 OS	Cytokinetic bridge	Intensity	Intensity
HPA031107	U-2 OS	Cytosol
HPA031107	U-251 MG	Microtubules
HPA031107	U-251 MG	Cytosol

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Cytokinetic bridge

GENE INFORMATION
Gene name	FRYL (HGNC Symbol)
Synonyms	AF4p12, DKFZp686E205, KIAA0826
Description	FRY-like (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	p11
Chromosome location (bp)	48497361 - 48780322
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000075539 (version 83.38)
Entrez gene	285527
UniProt	O94915 (UniProt - Evidence at protein level)
neXtProt	NX_O94915
Antibodypedia	FRYL antibodies

PROTEIN BROWSER

FRYL-002	FRYL-005	FRYL-007	FRYL-011	FRYL-014	FRYL-019	FRYL-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FRYL-002 ENSP00000422408 ENST00000507873	O94915 [Direct mapping] Protein furry homolog-like Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000902 [cell morphogenesis] GO:0005938 [cell cortex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0030427 [site of polarized growth] GO:0031175 [neuron projection development] GO:0090527 [actin filament reorganization] Show all	403 aa 45.6 kDa	No	0
FRYL-005 ENSP00000425344 ENST00000514617	H0Y9X0 [Direct mapping] Protein furry homolog-like Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	1455 aa 162.8 kDa	No	0
FRYL-007 ENSP00000421584 ENST00000507711	F2Z2S2 [Direct mapping] Protein furry homolog-like Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	1553 aa 176.6 kDa	No	0
FRYL-011 ENSP00000426064 ENST00000503238	O94915 [Direct mapping] Protein furry homolog-like Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000902 [cell morphogenesis] GO:0005488 [binding] GO:0005938 [cell cortex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0030427 [site of polarized growth] GO:0031175 [neuron projection development] GO:0090527 [actin filament reorganization] Show all	3013 aa 339.6 kDa	No	0
FRYL-014 ENSP00000425592 ENST00000506685	D6RJI4 [Direct mapping] Protein furry homolog-like Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	471 aa 53.6 kDa	No	0
FRYL-019 ENSP00000422988 ENST00000505759	D6R9B9 [Direct mapping] Protein furry homolog-like Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		191 aa 21.7 kDa	No	0
FRYL-201 ENSP00000351113 ENST00000358350	O94915 [Direct mapping] Protein furry homolog-like Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000902 [cell morphogenesis] GO:0005488 [binding] GO:0005938 [cell cortex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0030427 [site of polarized growth] GO:0031175 [neuron projection development] GO:0090527 [actin filament reorganization] Show all	3013 aa 339.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.