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DLG1

GENERAL INFORMATION

Gene name

 DLG1

Gene description

 Discs, large homolog 1 (Drosophila)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 17
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous membranous and cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB016307
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Caudate

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DLG1 (HGNC Symbol)

Synonyms

 dJ1061C18.1.1, DLGH1, hdlg, SAP-97, SAP97

Description

 Discs, large homolog 1 (Drosophila) (HGNC Symbol)

Entrez gene summary

 This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known. [provided by RefSeq, Feb 2011]

Chromosome

 3

Cytoband

 q29

Chromosome location (bp)

 197042560 - 197299300

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000075711 (version 83.38)

Entrez gene

 1739

UniProt

 Q12959 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12959

Antibodypedia

 DLG1 antibodies

PROTEIN BROWSER
«
DLG1-001
DLG1-002
DLG1-003
DLG1-004
DLG1-005
DLG1-007
DLG1-008
DLG1-009
DLG1-011
DLG1-013
DLG1-019
DLG1-020
DLG1-021
DLG1-023
DLG1-024
DLG1-027
DLG1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DLG1-001
ENSP00000345731
ENST00000346964
Q12959 [Direct mapping]
Disks large homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001657 [ureteric bud development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001771 [immunological synapse formation]
GO:0001772 [immunological synapse]
GO:0001935 [endothelial cell proliferation]
GO:0002088 [lens development in camera-type eye]
GO:0002369 [T cell cytokine production]
GO:0004385 [guanylate kinase activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0005515 [protein binding]
GO:0005605 [basal lamina]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0006470 [protein dephosphorylation]
GO:0007015 [actin filament organization]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008022 [protein C-terminus binding]
GO:0008092 [cytoskeletal protein binding]
GO:0008104 [protein localization]
GO:0008284 [positive regulation of cell proliferation]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0008360 [regulation of cell shape]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0014069 [postsynaptic density]
GO:0014704 [intercalated disc]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0030054 [cell junction]
GO:0030432 [peristalsis]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0030953 [astral microtubule organization]
GO:0031253 [cell projection membrane]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031579 [membrane raft organization]
GO:0031594 [neuromuscular junction]
GO:0031641 [regulation of myelination]
GO:0032147 [activation of protein kinase activity]
GO:0032947 [protein complex scaffold]
GO:0033268 [node of Ranvier]
GO:0034629 [cellular protein complex localization]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0035748 [myelin sheath abaxonal region]
GO:0042110 [T cell activation]
GO:0042130 [negative regulation of T cell proliferation]
GO:0042383 [sarcolemma]
GO:0042391 [regulation of membrane potential]
GO:0042982 [amyloid precursor protein metabolic process]
GO:0043113 [receptor clustering]
GO:0043219 [lateral loop]
GO:0043268 [positive regulation of potassium ion transport]
GO:0043622 [cortical microtubule organization]
GO:0044325 [ion channel binding]
GO:0045121 [membrane raft]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048608 [reproductive structure development]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0048729 [tissue morphogenesis]
GO:0048745 [smooth muscle tissue development]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051660 [establishment of centrosome localization]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060022 [hard palate development]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070830 [bicellular tight junction assembly]
GO:0072659 [protein localization to plasma membrane]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0097016 [L27 domain binding]
GO:0097025 [MPP7-DLG1-LIN7 complex]
GO:0097120 [receptor localization to synapse]
GO:1902305 [regulation of sodium ion transmembrane transport]
GO:1903753 [negative regulation of p38MAPK cascade]
Show all
 926 aa
103.3 kDa 		No 0
DLG1-002
ENSP00000390403
ENST00000412364
F2Z2L0 [Direct mapping]
Disks large homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 106 aa
12.2 kDa 		No 0
DLG1-003
ENSP00000376185
ENST00000392380
A8MUT6 [Direct mapping]
Disks large homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 208 aa
23.3 kDa 		No 0
DLG1-004
ENSP00000400169
ENST00000434148
C9J110 [Direct mapping]
Disks large homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 36 aa
4.4 kDa 		No 0
DLG1-005
ENSP00000393771
ENST00000436682
C9JUA9 [Direct mapping]
Disks large homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 123 aa
14.3 kDa 		No 0
DLG1-007
ENSP00000391732
ENST00000448528
Q12959 [Direct mapping]
Disks large homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001772 [immunological synapse]
GO:0001935 [endothelial cell proliferation]
GO:0004385 [guanylate kinase activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0006470 [protein dephosphorylation]
GO:0007015 [actin filament organization]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008022 [protein C-terminus binding]
GO:0008092 [cytoskeletal protein binding]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0008360 [regulation of cell shape]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0014069 [postsynaptic density]
GO:0014704 [intercalated disc]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0030054 [cell junction]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0030953 [astral microtubule organization]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0034629 [cellular protein complex localization]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0042383 [sarcolemma]
GO:0042391 [regulation of membrane potential]
GO:0043113 [receptor clustering]
GO:0043268 [positive regulation of potassium ion transport]
GO:0043622 [cortical microtubule organization]
GO:0044325 [ion channel binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045211 [postsynaptic membrane]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051660 [establishment of centrosome localization]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070830 [bicellular tight junction assembly]
GO:0072659 [protein localization to plasma membrane]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0097016 [L27 domain binding]
GO:0097025 [MPP7-DLG1-LIN7 complex]
GO:0097120 [receptor localization to synapse]
GO:1902305 [regulation of sodium ion transmembrane transport]
GO:1903753 [negative regulation of p38MAPK cascade]
Show all
 904 aa
100.5 kDa 		No 0
DLG1-008
ENSP00000407531
ENST00000419354
Q12959 [Direct mapping]
Disks large homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001772 [immunological synapse]
GO:0001935 [endothelial cell proliferation]
GO:0004385 [guanylate kinase activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0006470 [protein dephosphorylation]
GO:0007015 [actin filament organization]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008022 [protein C-terminus binding]
GO:0008092 [cytoskeletal protein binding]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0008360 [regulation of cell shape]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0014069 [postsynaptic density]
GO:0014704 [intercalated disc]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0030054 [cell junction]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0030953 [astral microtubule organization]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0034629 [cellular protein complex localization]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0042383 [sarcolemma]
GO:0042391 [regulation of membrane potential]
GO:0043113 [receptor clustering]
GO:0043268 [positive regulation of potassium ion transport]
GO:0043622 [cortical microtubule organization]
GO:0044325 [ion channel binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045211 [postsynaptic membrane]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051660 [establishment of centrosome localization]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070830 [bicellular tight junction assembly]
GO:0072659 [protein localization to plasma membrane]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0097016 [L27 domain binding]
GO:0097025 [MPP7-DLG1-LIN7 complex]
GO:0097120 [receptor localization to synapse]
GO:1902305 [regulation of sodium ion transmembrane transport]
GO:1903753 [negative regulation of p38MAPK cascade]
Show all
 904 aa
100.5 kDa 		No 0
DLG1-009
ENSP00000414189
ENST00000419553
C9JN61 [Direct mapping]
Disks large homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 154 aa
17.7 kDa 		No 0
DLG1-011
ENSP00000398939
ENST00000452595
Q12959 [Direct mapping]
Disks large homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001772 [immunological synapse]
GO:0001935 [endothelial cell proliferation]
GO:0004385 [guanylate kinase activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0006470 [protein dephosphorylation]
GO:0007015 [actin filament organization]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008022 [protein C-terminus binding]
GO:0008092 [cytoskeletal protein binding]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0008360 [regulation of cell shape]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0014069 [postsynaptic density]
GO:0014704 [intercalated disc]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0030054 [cell junction]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0030953 [astral microtubule organization]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0034629 [cellular protein complex localization]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0042383 [sarcolemma]
GO:0042391 [regulation of membrane potential]
GO:0043113 [receptor clustering]
GO:0043268 [positive regulation of potassium ion transport]
GO:0043622 [cortical microtubule organization]
GO:0044325 [ion channel binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045211 [postsynaptic membrane]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051660 [establishment of centrosome localization]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070830 [bicellular tight junction assembly]
GO:0072659 [protein localization to plasma membrane]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0097016 [L27 domain binding]
GO:0097025 [MPP7-DLG1-LIN7 complex]
GO:0097120 [receptor localization to synapse]
GO:1902305 [regulation of sodium ion transmembrane transport]
GO:1903753 [negative regulation of p38MAPK cascade]
Show all
 788 aa
87.2 kDa 		No 0
DLG1-013
ENSP00000376187
ENST00000392382
Q12959 [Direct mapping]
Disks large homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001772 [immunological synapse]
GO:0001935 [endothelial cell proliferation]
GO:0004385 [guanylate kinase activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0006470 [protein dephosphorylation]
GO:0007015 [actin filament organization]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008022 [protein C-terminus binding]
GO:0008092 [cytoskeletal protein binding]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0008360 [regulation of cell shape]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0014069 [postsynaptic density]
GO:0014704 [intercalated disc]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0030054 [cell junction]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0030953 [astral microtubule organization]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0034629 [cellular protein complex localization]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0042383 [sarcolemma]
GO:0042391 [regulation of membrane potential]
GO:0043113 [receptor clustering]
GO:0043268 [positive regulation of potassium ion transport]
GO:0043622 [cortical microtubule organization]
GO:0044325 [ion channel binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045211 [postsynaptic membrane]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051660 [establishment of centrosome localization]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070830 [bicellular tight junction assembly]
GO:0072659 [protein localization to plasma membrane]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0097016 [L27 domain binding]
GO:0097025 [MPP7-DLG1-LIN7 complex]
GO:0097120 [receptor localization to synapse]
GO:1902305 [regulation of sodium ion transmembrane transport]
GO:1903753 [negative regulation of p38MAPK cascade]
Show all
 871 aa
97.1 kDa 		No 0
DLG1-019
ENSP00000413238
ENST00000422288
Q12959 [Direct mapping]
Disks large homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001772 [immunological synapse]
GO:0001935 [endothelial cell proliferation]
GO:0004385 [guanylate kinase activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0006470 [protein dephosphorylation]
GO:0007015 [actin filament organization]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008022 [protein C-terminus binding]
GO:0008092 [cytoskeletal protein binding]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0008360 [regulation of cell shape]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0014069 [postsynaptic density]
GO:0014704 [intercalated disc]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0030054 [cell junction]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0030953 [astral microtubule organization]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0034629 [cellular protein complex localization]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0042383 [sarcolemma]
GO:0042391 [regulation of membrane potential]
GO:0043113 [receptor clustering]
GO:0043268 [positive regulation of potassium ion transport]
GO:0043622 [cortical microtubule organization]
GO:0044325 [ion channel binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045211 [postsynaptic membrane]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051660 [establishment of centrosome localization]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070830 [bicellular tight junction assembly]
GO:0072659 [protein localization to plasma membrane]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0097016 [L27 domain binding]
GO:0097025 [MPP7-DLG1-LIN7 complex]
GO:0097120 [receptor localization to synapse]
GO:1902305 [regulation of sodium ion transmembrane transport]
GO:1903753 [negative regulation of p38MAPK cascade]
Show all
 853 aa
95.2 kDa 		No 0
DLG1-020
ENSP00000396658
ENST00000443183
Q12959 [Direct mapping]
Disks large homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001772 [immunological synapse]
GO:0001935 [endothelial cell proliferation]
GO:0004385 [guanylate kinase activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0006470 [protein dephosphorylation]
GO:0007015 [actin filament organization]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008022 [protein C-terminus binding]
GO:0008092 [cytoskeletal protein binding]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0008360 [regulation of cell shape]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0014069 [postsynaptic density]
GO:0014704 [intercalated disc]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0030054 [cell junction]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0030953 [astral microtubule organization]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0034629 [cellular protein complex localization]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0042383 [sarcolemma]
GO:0042391 [regulation of membrane potential]
GO:0043113 [receptor clustering]
GO:0043268 [positive regulation of potassium ion transport]
GO:0043622 [cortical microtubule organization]
GO:0044325 [ion channel binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045211 [postsynaptic membrane]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051660 [establishment of centrosome localization]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070830 [bicellular tight junction assembly]
GO:0072659 [protein localization to plasma membrane]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0097016 [L27 domain binding]
GO:0097025 [MPP7-DLG1-LIN7 complex]
GO:0097120 [receptor localization to synapse]
GO:1902305 [regulation of sodium ion transmembrane transport]
GO:1903753 [negative regulation of p38MAPK cascade]
Show all
 800 aa
88.5 kDa 		No 0
DLG1-021
ENSP00000398702
ENST00000447466
H7C166 [Direct mapping]
Disks large homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 286 aa
30.5 kDa 		No 0
DLG1-023
ENSP00000396474
ENST00000456699
C9JCP6 [Direct mapping]
Disks large homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 179 aa
20.4 kDa 		No 0
DLG1-024
ENSP00000412579
ENST00000453607
C9IYP1 [Direct mapping]
Disks large homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 122 aa
13.3 kDa 		No 0
DLG1-027
ENSP00000411278
ENST00000450955
Q12959 [Direct mapping]
Disks large homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001772 [immunological synapse]
GO:0001935 [endothelial cell proliferation]
GO:0004385 [guanylate kinase activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0006470 [protein dephosphorylation]
GO:0007015 [actin filament organization]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008022 [protein C-terminus binding]
GO:0008092 [cytoskeletal protein binding]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0008360 [regulation of cell shape]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0014069 [postsynaptic density]
GO:0014704 [intercalated disc]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0030054 [cell junction]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0030953 [astral microtubule organization]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0034629 [cellular protein complex localization]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0042383 [sarcolemma]
GO:0042391 [regulation of membrane potential]
GO:0043113 [receptor clustering]
GO:0043268 [positive regulation of potassium ion transport]
GO:0043622 [cortical microtubule organization]
GO:0044325 [ion channel binding]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045211 [postsynaptic membrane]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046037 [GMP metabolic process]
GO:0046710 [GDP metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051660 [establishment of centrosome localization]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070830 [bicellular tight junction assembly]
GO:0072659 [protein localization to plasma membrane]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0097016 [L27 domain binding]
GO:0097025 [MPP7-DLG1-LIN7 complex]
GO:0097120 [receptor localization to synapse]
GO:1902305 [regulation of sodium ion transmembrane transport]
GO:1903753 [negative regulation of p38MAPK cascade]
Show all
 893 aa
99.9 kDa 		No 0
DLG1-201
ENSP00000350303
ENST00000357674
A0A0C4DFT3 [Direct mapping]
Disks large homolog 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0008328 [ionotropic glutamate receptor complex]
GO:0014069 [postsynaptic density]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043113 [receptor clustering]
GO:0045197 [establishment or maintenance of epithelial cell apical/basal polarity]
GO:0045211 [postsynaptic membrane]
GO:0097120 [receptor localization to synapse]
Show all
 892 aa
99.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.