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PAX2

CANCER ATLAS

Gene description

 Paired box 2

Protein class

 Disease related genes, Predicted intracellular proteins, Predicted secreted proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047704
CAB013024

GENE INFORMATION

Gene name

 PAX2

Synonyms

Description

 Paired box 2 (HGNC Symbol)

Entrez gene summary

 PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Chromosome

 10

Cytoband

 q24.31

Chromosome location (bp)

 100735603 - 100829941

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000075891 (version 83.38)

Entrez gene

 5076

UniProt

 Q02962 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02962

Antibodypedia

 PAX2 antibodies

PROTEIN BROWSER
PAX2-001
PAX2-002
PAX2-003
PAX2-005
PAX2-006
PAX2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAX2-001
ENSP00000347385
ENST00000355243
Q02962 [Direct mapping]
Paired box protein Pax-2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0001655 [urogenital system development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001709 [cell fate determination]
GO:0001823 [mesonephros development]
GO:0001843 [neural tube closure]
GO:0002072 [optic cup morphogenesis involved in camera-type eye development]
GO:0003337 [mesenchymal to epithelial transition involved in metanephros morphogenesis]
GO:0003406 [retinal pigment epithelium development]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005815 [microtubule organizing center]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007409 [axonogenesis]
GO:0007501 [mesodermal cell fate specification]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0010001 [glial cell differentiation]
GO:0016175 [superoxide-generating NADPH oxidase activity]
GO:0021554 [optic nerve development]
GO:0021631 [optic nerve morphogenesis]
GO:0021633 [optic nerve structural organization]
GO:0021650 [vestibulocochlear nerve formation]
GO:0032993 [protein-DNA complex]
GO:0034451 [centriolar satellite]
GO:0035566 [regulation of metanephros size]
GO:0035799 [ureter maturation]
GO:0039003 [pronephric field specification]
GO:0042472 [inner ear morphogenesis]
GO:0043010 [camera-type eye development]
GO:0043066 [negative regulation of apoptotic process]
GO:0043069 [negative regulation of programmed cell death]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043234 [protein complex]
GO:0043491 [protein kinase B signaling]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045918 [negative regulation of cytolysis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048793 [pronephros development]
GO:0048854 [brain morphogenesis]
GO:0048863 [stem cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0055114 [oxidation-reduction process]
GO:0060231 [mesenchymal to epithelial transition]
GO:0061360 [optic chiasma development]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071300 [cellular response to retinoic acid]
GO:0071333 [cellular response to glucose stimulus]
GO:0072075 [metanephric mesenchyme development]
GO:0072108 [positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis]
GO:0072162 [metanephric mesenchymal cell differentiation]
GO:0072179 [nephric duct formation]
GO:0072189 [ureter development]
GO:0072205 [metanephric collecting duct development]
GO:0072207 [metanephric epithelium development]
GO:0072221 [metanephric distal convoluted tubule development]
GO:0072289 [metanephric nephron tubule formation]
GO:0072300 [positive regulation of metanephric glomerulus development]
GO:0072305 [negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis]
GO:0072307 [regulation of metanephric nephron tubule epithelial cell differentiation]
GO:0072593 [reactive oxygen species metabolic process]
GO:0090102 [cochlea development]
GO:0090103 [cochlea morphogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:1900212 [negative regulation of mesenchymal cell apoptotic process involved in metanephros development]
GO:1900215 [negative regulation of apoptotic process involved in metanephric collecting duct development]
GO:1900218 [negative regulation of apoptotic process involved in metanephric nephron tubule development]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
GO:2000594 [positive regulation of metanephric DCT cell differentiation]
GO:2000597 [positive regulation of optic nerve formation]
Show all
 394 aa
42.2 kDa 		No 0
PAX2-002
ENSP00000359319
ENST00000370296
Q02962 [Direct mapping]
Paired box protein Pax-2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0001655 [urogenital system development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001709 [cell fate determination]
GO:0001823 [mesonephros development]
GO:0001843 [neural tube closure]
GO:0002072 [optic cup morphogenesis involved in camera-type eye development]
GO:0003337 [mesenchymal to epithelial transition involved in metanephros morphogenesis]
GO:0003406 [retinal pigment epithelium development]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005764 [lysosome]
GO:0005815 [microtubule organizing center]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007409 [axonogenesis]
GO:0007501 [mesodermal cell fate specification]
GO:0007568 [aging]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0010001 [glial cell differentiation]
GO:0016175 [superoxide-generating NADPH oxidase activity]
GO:0021554 [optic nerve development]
GO:0021631 [optic nerve morphogenesis]
GO:0021633 [optic nerve structural organization]
GO:0021650 [vestibulocochlear nerve formation]
GO:0031667 [response to nutrient levels]
GO:0032993 [protein-DNA complex]
GO:0034451 [centriolar satellite]
GO:0035566 [regulation of metanephros size]
GO:0035799 [ureter maturation]
GO:0039003 [pronephric field specification]
GO:0042472 [inner ear morphogenesis]
GO:0043010 [camera-type eye development]
GO:0043066 [negative regulation of apoptotic process]
GO:0043069 [negative regulation of programmed cell death]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043234 [protein complex]
GO:0043491 [protein kinase B signaling]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045918 [negative regulation of cytolysis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048513 [organ development]
GO:0048793 [pronephros development]
GO:0048854 [brain morphogenesis]
GO:0048863 [stem cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0055114 [oxidation-reduction process]
GO:0060231 [mesenchymal to epithelial transition]
GO:0061360 [optic chiasma development]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071300 [cellular response to retinoic acid]
GO:0071333 [cellular response to glucose stimulus]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0072075 [metanephric mesenchyme development]
GO:0072108 [positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis]
GO:0072162 [metanephric mesenchymal cell differentiation]
GO:0072179 [nephric duct formation]
GO:0072189 [ureter development]
GO:0072205 [metanephric collecting duct development]
GO:0072207 [metanephric epithelium development]
GO:0072221 [metanephric distal convoluted tubule development]
GO:0072289 [metanephric nephron tubule formation]
GO:0072300 [positive regulation of metanephric glomerulus development]
GO:0072305 [negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis]
GO:0072307 [regulation of metanephric nephron tubule epithelial cell differentiation]
GO:0072593 [reactive oxygen species metabolic process]
GO:0090102 [cochlea development]
GO:0090103 [cochlea morphogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:1900212 [negative regulation of mesenchymal cell apoptotic process involved in metanephros development]
GO:1900215 [negative regulation of apoptotic process involved in metanephric collecting duct development]
GO:1900218 [negative regulation of apoptotic process involved in metanephric nephron tubule development]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
GO:2000594 [positive regulation of metanephric DCT cell differentiation]
GO:2000597 [positive regulation of optic nerve formation]
Show all
 396 aa
42 kDa 		No 0
PAX2-003
ENSP00000398652
ENST00000427256
Q5SZP1 [Direct mapping]
Paired box protein Pax-2
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
Show all
 214 aa
23 kDa 		No 0
PAX2-005
ENSP00000452489
ENST00000554172
G3V5S4 [Direct mapping]
Paired box protein Pax-2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
Show all
 304 aa
32.4 kDa 		Yes 0
PAX2-006
ENSP00000355069
ENST00000361791
A0A0A0MRH7 [Direct mapping]
Paired box protein Pax-2
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
Show all
 393 aa
42.2 kDa 		No 0
PAX2-201
ENSP00000396259
ENST00000428433
Q02962 [Direct mapping]
Paired box protein Pax-2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0001655 [urogenital system development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001709 [cell fate determination]
GO:0001823 [mesonephros development]
GO:0001843 [neural tube closure]
GO:0002072 [optic cup morphogenesis involved in camera-type eye development]
GO:0003337 [mesenchymal to epithelial transition involved in metanephros morphogenesis]
GO:0003406 [retinal pigment epithelium development]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005815 [microtubule organizing center]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007409 [axonogenesis]
GO:0007501 [mesodermal cell fate specification]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0010001 [glial cell differentiation]
GO:0016175 [superoxide-generating NADPH oxidase activity]
GO:0021554 [optic nerve development]
GO:0021631 [optic nerve morphogenesis]
GO:0021633 [optic nerve structural organization]
GO:0021650 [vestibulocochlear nerve formation]
GO:0032993 [protein-DNA complex]
GO:0034451 [centriolar satellite]
GO:0035566 [regulation of metanephros size]
GO:0035799 [ureter maturation]
GO:0039003 [pronephric field specification]
GO:0042472 [inner ear morphogenesis]
GO:0043010 [camera-type eye development]
GO:0043066 [negative regulation of apoptotic process]
GO:0043069 [negative regulation of programmed cell death]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043234 [protein complex]
GO:0043491 [protein kinase B signaling]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045918 [negative regulation of cytolysis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048793 [pronephros development]
GO:0048854 [brain morphogenesis]
GO:0048863 [stem cell differentiation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0055114 [oxidation-reduction process]
GO:0060231 [mesenchymal to epithelial transition]
GO:0061360 [optic chiasma development]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071300 [cellular response to retinoic acid]
GO:0071333 [cellular response to glucose stimulus]
GO:0072075 [metanephric mesenchyme development]
GO:0072108 [positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis]
GO:0072162 [metanephric mesenchymal cell differentiation]
GO:0072179 [nephric duct formation]
GO:0072189 [ureter development]
GO:0072205 [metanephric collecting duct development]
GO:0072207 [metanephric epithelium development]
GO:0072221 [metanephric distal convoluted tubule development]
GO:0072289 [metanephric nephron tubule formation]
GO:0072300 [positive regulation of metanephric glomerulus development]
GO:0072305 [negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis]
GO:0072307 [regulation of metanephric nephron tubule epithelial cell differentiation]
GO:0072593 [reactive oxygen species metabolic process]
GO:0090102 [cochlea development]
GO:0090103 [cochlea morphogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:1900212 [negative regulation of mesenchymal cell apoptotic process involved in metanephros development]
GO:1900215 [negative regulation of apoptotic process involved in metanephric collecting duct development]
GO:1900218 [negative regulation of apoptotic process involved in metanephric nephron tubule development]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
GO:2000594 [positive regulation of metanephric DCT cell differentiation]
GO:2000597 [positive regulation of optic nerve formation]
Show all
 417 aa
44.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.