Cell atlas - REXO2 - The Human Protein Atlas

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REXO2

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Focal adhesion sites
	Mitochondria
	Nucleoli

Human cell
	Actin Filaments
	Mitochondria
	Nucleoli

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GENERAL INFORMATION
Gene name	REXO2
Gene description	RNA exonuclease 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the nucleoli & focal adhesion sites.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)
Additional location	In addition localized to the Nucleoli (approved), Focal adhesion sites (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA038450
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the nucleoli & focal adhesion sites.

Main location

Mitochondria (supported)

Additional location

Nucleoli (approved), Focal adhesion sites (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA038450	A-431	Mitochondria
	HPA038450	U-2 OS	Nucleoli
			Focal adhesion sites
			Mitochondria
	HPA038450	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	REXO2 (HGNC Symbol)
Synonyms	CGI-114, DKFZP566E144, SFN
Description	RNA exonuclease 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]
Chromosome	11
Cytoband	q23.2
Chromosome location (bp)	114439386 - 114450279
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000076043 (version 83.38)
Entrez gene	25996
UniProt	Q9Y3B8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y3B8
Antibodypedia	REXO2 antibodies

PROTEIN BROWSER

REXO2-001	REXO2-003	REXO2-006	REXO2-007	REXO2-012	REXO2-014	REXO2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
REXO2-001 ENSP00000265881 ENST00000265881	Q9Y3B8 [Direct mapping] Oligoribonuclease, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000175 [3'-5'-exoribonuclease activity] GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0005758 [mitochondrial intermembrane space] GO:0005759 [mitochondrial matrix] GO:0005925 [focal adhesion] GO:0006139 [nucleobase-containing compound metabolic process] GO:0008408 [3'-5' exonuclease activity] GO:0009117 [nucleotide metabolic process] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic] Show all	237 aa 26.8 kDa	No	0
REXO2-003 ENSP00000443842 ENST00000539275	Q9BTR4 [Direct mapping] Oligoribonuclease, mitochondrial; REXO2 protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000175 [3'-5'-exoribonuclease activity] GO:0003676 [nucleic acid binding] GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic] Show all	79 aa 8.3 kDa	No	0
REXO2-006 ENSP00000437460 ENST00000544196	F5H6P8 [Direct mapping] Oligoribonuclease, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000175 [3'-5'-exoribonuclease activity] GO:0003676 [nucleic acid binding] GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic] Show all	85 aa 9.1 kDa	No	0
REXO2-007 ENSP00000440665 ENST00000539754	F5GYG5 [Direct mapping] Oligoribonuclease, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000175 [3'-5'-exoribonuclease activity] GO:0003676 [nucleic acid binding] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0005925 [focal adhesion] GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic] Show all	222 aa 25.3 kDa	No	0
REXO2-012 ENSP00000444421 ENST00000539119	H0YGR4 [Direct mapping] Oligoribonuclease, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000175 [3'-5'-exoribonuclease activity] GO:0003676 [nucleic acid binding] GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic] Show all	192 aa 22 kDa	No	0
REXO2-014 ENSP00000441844 ENST00000544827	H0YG54 [Direct mapping] Oligoribonuclease, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000175 [3'-5'-exoribonuclease activity] GO:0003676 [nucleic acid binding] GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic] Show all	188 aa 21.8 kDa	No	0
REXO2-201 ENSP00000480535 ENST00000611665	Q9Y3B8 [Direct mapping] Oligoribonuclease, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000175 [3'-5'-exoribonuclease activity] GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0005758 [mitochondrial intermembrane space] GO:0005759 [mitochondrial matrix] GO:0005925 [focal adhesion] GO:0006139 [nucleobase-containing compound metabolic process] GO:0008408 [3'-5' exonuclease activity] GO:0009117 [nucleotide metabolic process] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic] Show all	237 aa 26.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.