Cell atlas - NT5C2 - The Human Protein Atlas

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NT5C2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	NT5C2
Gene description	5'-nucleotidase, cytosolic II
Protein class	Cancer-related genes Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	NT5C2 (HGNC Symbol)
Synonyms	cN-II, GMP, NT5B, PNT5, SPG65
Description	5'-nucleotidase, cytosolic II (HGNC Symbol)
Entrez gene summary	This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. [provided by RefSeq, Oct 2011]
Chromosome	10
Cytoband
Chromosome location (bp)	103088017 - 103193306
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000076685 (version 83.38)
Entrez gene	22978
UniProt	P49902 (UniProt - Evidence at protein level)
neXtProt	NX_P49902
Antibodypedia	NT5C2 antibodies

PROTEIN BROWSER

NT5C2-001	NT5C2-005	NT5C2-009	NT5C2-010	NT5C2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NT5C2-001 ENSP00000383960 ENST00000404739	P49902 [Direct mapping] Cytosolic purine 5'-nucleotidase Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006195 [purine nucleotide catabolic process] GO:0008253 [5'-nucleotidase activity] GO:0016310 [phosphorylation] GO:0017144 [drug metabolic process] GO:0044281 [small molecule metabolic process] GO:0046040 [IMP metabolic process] GO:0046085 [adenosine metabolic process] GO:0046872 [metal ion binding] GO:0050146 [nucleoside phosphotransferase activity] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	561 aa 65 kDa	No	0
NT5C2-005 ENSP00000411330 ENST00000458345	Q5JUV3 [Direct mapping] Cytosolic purine 5'-nucleotidase Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0046040 [IMP metabolic process] GO:0046085 [adenosine metabolic process] Show all	174 aa 20.4 kDa	No	0
NT5C2-009 ENSP00000408112 ENST00000421281	Q5JUV6 [Direct mapping] Cytosolic purine 5'-nucleotidase Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0046040 [IMP metabolic process] GO:0046085 [adenosine metabolic process] Show all	147 aa 16.6 kDa	No	0
NT5C2-010 ENSP00000474247 ENST00000470299	S4R3E7 [Direct mapping] Cytosolic purine 5'-nucleotidase Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0046040 [IMP metabolic process] GO:0046085 [adenosine metabolic process] Show all	44 aa 5.2 kDa	No	0
NT5C2-201 ENSP00000339479 ENST00000343289	P49902 [Direct mapping] Cytosolic purine 5'-nucleotidase Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006195 [purine nucleotide catabolic process] GO:0008253 [5'-nucleotidase activity] GO:0016310 [phosphorylation] GO:0016311 [dephosphorylation] GO:0017144 [drug metabolic process] GO:0044281 [small molecule metabolic process] GO:0046040 [IMP metabolic process] GO:0046085 [adenosine metabolic process] GO:0046872 [metal ion binding] GO:0050146 [nucleoside phosphotransferase activity] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	561 aa 65 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.