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Several cases of hepatocellular carcinomas, malignant carcinoids, malignant gliomas, breast and prostate cancers were moderate to strongly stained. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
GPC4 (HGNC Symbol)
Synonyms
K-glypican
Description
Glypican 4 (HGNC Symbol)
Entrez gene summary
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008]