Cell atlas - MBNL3 - The Human Protein Atlas

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MBNL3

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Vesicles

Human cell
	Golgi Apparatus
	Vesicles

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GENERAL INFORMATION
Gene name	MBNL3
Gene description	Muscleblind-like splicing regulator 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the Golgi apparatus.
RNA cell category	Cell line enhanced (Hep G2, CACO-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Additional location	In addition localized to the Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA001584
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2, CACO-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the Golgi apparatus.

Main location

Vesicles (approved)

Additional location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA001584	A-431	Golgi apparatus
	HPA001584	A-431	Vesicles
	HPA001584	U-2 OS	Vesicles
	HPA001584	U-251 MG	Vesicles

GENE INFORMATION
Gene name	MBNL3 (HGNC Symbol)
Synonyms	CHCR, FLJ11316, MBLX39, MBXL
Description	Muscleblind-like splicing regulator 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the muscleblind-like family of proteins. The encoded protein may function in regulation of alternative splicing and may play a role in the pathophysiology of myotonic dystrophy. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009]
Chromosome	X
Cytoband	q26.2
Chromosome location (bp)	132369317 - 132489968
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000076770 (version 83.38)
Entrez gene	55796
UniProt	Q9NUK0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NUK0
Antibodypedia	MBNL3 antibodies

PROTEIN BROWSER

MBNL3-001	MBNL3-002	MBNL3-003	MBNL3-004	MBNL3-005	MBNL3-006	MBNL3-008	MBNL3-009	MBNL3-201	MBNL3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MBNL3-001 ENSP00000359876 ENST00000370839	Q9NUK0 [Direct mapping] Muscleblind-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006397 [mRNA processing] GO:0007275 [multicellular organismal development] GO:0008380 [RNA splicing] GO:0043484 [regulation of RNA splicing] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] Show all	334 aa 36.4 kDa	No	0
MBNL3-002 ENSP00000359890 ENST00000370853	Q9NUK0 [Direct mapping] Muscleblind-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006397 [mRNA processing] GO:0007275 [multicellular organismal development] GO:0008380 [RNA splicing] GO:0043484 [regulation of RNA splicing] GO:0044822 [poly(A) RNA binding] GO:0045662 [negative regulation of myoblast differentiation] GO:0046872 [metal ion binding] Show all	354 aa 38.5 kDa	No	0
MBNL3-003 ENSP00000359886 ENST00000370849	Q9NUK0 [Direct mapping] Muscleblind-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006397 [mRNA processing] GO:0007275 [multicellular organismal development] GO:0008380 [RNA splicing] GO:0043484 [regulation of RNA splicing] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] Show all	304 aa 32.9 kDa	No	0
MBNL3-004 ENSP00000359881 ENST00000370844	Q9NUK0 [Direct mapping] Muscleblind-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006397 [mRNA processing] GO:0007275 [multicellular organismal development] GO:0008380 [RNA splicing] GO:0043484 [regulation of RNA splicing] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] Show all	258 aa 27.7 kDa	No	0
MBNL3-005 ENSP00000359894 ENST00000370857	B1AKI6 [Direct mapping] Muscleblind-like protein 3 Show all	Predicted intracellular proteins Show all	GO:0046872 [metal ion binding] Show all	342 aa 37.4 kDa	No	0
MBNL3-006 ENSP00000402128 ENST00000421707	B1AKI5 [Direct mapping] Muscleblind-like protein 3 Show all	Predicted intracellular proteins Show all	GO:0046872 [metal ion binding] Show all	223 aa 24.2 kDa	No	0
MBNL3-008 ENSP00000406014 ENST00000436215	B1AKI4 [Direct mapping] Muscleblind-like protein 3 Show all	Predicted intracellular proteins Show all	GO:0046872 [metal ion binding] Show all	242 aa 26 kDa	No	0
MBNL3-009 ENSP00000412065 ENST00000442191	B1AKI2 [Direct mapping] Muscleblind-like protein 3 Show all	Predicted intracellular proteins Show all	GO:0046872 [metal ion binding] Show all	150 aa 16 kDa	No	0
MBNL3-201 ENSP00000377848 ENST00000394311	Q9NUK0 [Direct mapping] Muscleblind-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006397 [mRNA processing] GO:0007275 [multicellular organismal development] GO:0008380 [RNA splicing] GO:0043484 [regulation of RNA splicing] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] Show all	258 aa 27.7 kDa	No	0
MBNL3-202 ENSP00000439618 ENST00000538204	Q9NUK0 [Direct mapping] Muscleblind-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006397 [mRNA processing] GO:0007275 [multicellular organismal development] GO:0008380 [RNA splicing] GO:0043484 [regulation of RNA splicing] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] Show all	292 aa 31.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.