Cell atlas - STXBP2 - The Human Protein Atlas

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STXBP2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	STXBP2
Gene description	Syntaxin binding protein 2
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA015564 , HPA063868
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA015564	A-431	No staining
	HPA015564	RT4	Cytosol	Intensity
	HPA015564	U-2 OS	Cytosol
	HPA063868	PC-3	Cytosol
	HPA063868	U-2 OS	Cytosol

GENE INFORMATION
Gene name	STXBP2 (HGNC Symbol)
Synonyms	Hunc18b, UNC18B
Description	Syntaxin binding protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2013]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	7636881 - 7647873
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000076944 (version 83.38)
Entrez gene	6813
UniProt	Q15833 (UniProt - Evidence at protein level)
neXtProt	NX_Q15833
Antibodypedia	STXBP2 antibodies

PROTEIN BROWSER

STXBP2-001	STXBP2-002	STXBP2-003	STXBP2-006	STXBP2-007	STXBP2-019	STXBP2-022	STXBP2-201	STXBP2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STXBP2-001 ENSP00000221283 ENST00000221283	Q15833 [Direct mapping] Syntaxin-binding protein 2 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001909 [leukocyte mediated cytotoxicity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006904 [vesicle docking involved in exocytosis] GO:0015031 [protein transport] GO:0016192 [vesicle-mediated transport] GO:0030348 [syntaxin-3 binding] GO:0031201 [SNARE complex] GO:0042581 [specific granule] GO:0042582 [azurophil granule] GO:0043304 [regulation of mast cell degranulation] GO:0043312 [neutrophil degranulation] GO:0044194 [cytolytic granule] GO:0070062 [extracellular exosome] GO:0070820 [tertiary granule] Show all	593 aa 66.5 kDa	No	0
STXBP2-002 ENSP00000409471 ENST00000414284	Q15833 [Direct mapping] Syntaxin-binding protein 2 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001909 [leukocyte mediated cytotoxicity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006904 [vesicle docking involved in exocytosis] GO:0015031 [protein transport] GO:0016192 [vesicle-mediated transport] GO:0030348 [syntaxin-3 binding] GO:0031201 [SNARE complex] GO:0042581 [specific granule] GO:0042582 [azurophil granule] GO:0043304 [regulation of mast cell degranulation] GO:0043312 [neutrophil degranulation] GO:0044194 [cytolytic granule] GO:0070062 [extracellular exosome] GO:0070820 [tertiary granule] Show all	590 aa 66.1 kDa	No	0
STXBP2-003 ENSP00000413606 ENST00000441779	Q15833 [Direct mapping] Syntaxin-binding protein 2 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001909 [leukocyte mediated cytotoxicity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006887 [exocytosis] GO:0006904 [vesicle docking involved in exocytosis] GO:0015031 [protein transport] GO:0016192 [vesicle-mediated transport] GO:0016324 [apical plasma membrane] GO:0017075 [syntaxin-1 binding] GO:0030348 [syntaxin-3 binding] GO:0031201 [SNARE complex] GO:0042581 [specific granule] GO:0042582 [azurophil granule] GO:0043304 [regulation of mast cell degranulation] GO:0043312 [neutrophil degranulation] GO:0044194 [cytolytic granule] GO:0070062 [extracellular exosome] GO:0070820 [tertiary granule] Show all	604 aa 67.7 kDa	No	0
STXBP2-006 ENSP00000470313 ENST00000593535	M0QZ54 [Direct mapping] Syntaxin-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006904 [vesicle docking involved in exocytosis] GO:0016192 [vesicle-mediated transport] Show all	112 aa 12.6 kDa	No	0
STXBP2-007 ENSP00000471161 ENST00000595950	M0R0D4 [Direct mapping] Syntaxin-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006904 [vesicle docking involved in exocytosis] GO:0016192 [vesicle-mediated transport] Show all	169 aa 18.7 kDa	No	0
STXBP2-019 ENSP00000471737 ENST00000600702	M0R1A1 [Direct mapping] Syntaxin-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006904 [vesicle docking involved in exocytosis] GO:0016192 [vesicle-mediated transport] Show all	220 aa 24.5 kDa	No	0
STXBP2-022 ENSP00000473406 ENST00000602355	R4GMY7 [Direct mapping] Syntaxin-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006904 [vesicle docking involved in exocytosis] GO:0016192 [vesicle-mediated transport] Show all	128 aa 14.3 kDa	No	0
STXBP2-201 ENSP00000478797 ENST00000612033	A0A087WUN8 [Direct mapping] Syntaxin-binding protein 2 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006904 [vesicle docking involved in exocytosis] GO:0016021 [integral component of membrane] GO:0016192 [vesicle-mediated transport] Show all	395 aa 42.8 kDa	No	0
STXBP2-202 ENSP00000480468 ENST00000622853	A0A087WWS7 [Direct mapping] Syntaxin-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006904 [vesicle docking involved in exocytosis] GO:0016192 [vesicle-mediated transport] Show all	579 aa 64.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.