Cell atlas - CTTNBP2 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CTTNBP2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Midbody ring

Human cell
	Cytosol
	Microtubules

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	CTTNBP2
Gene description	Cortactin binding protein 2
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & midbody ring.
RNA cell category	Group enriched (HMC-1, HEL)
Protein evidence	Evidence at protein level
Main location	Localized to the Midbody ring (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition
Mouse	Localized to the Cytosol in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA044654
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HMC-1, HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & midbody ring.

Main location

Midbody ring (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA044654	HEK 293	Cytosol
	HPA044654	HeLa	Midbody ring	Intensity	Intensity
	HPA044654	HeLa	Cytosol
	HPA044654	U-2 OS	Midbody ring	Intensity	Intensity
	HPA044654	U-2 OS	Cytosol

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition

MOUSE CELLS

Main location

Cytosol

Mouse gene

ENSMUSG00000000416 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA044654	NIH 3T3	Cytosol

GENE INFORMATION
Gene name	CTTNBP2 (HGNC Symbol)
Synonyms	C7orf8, CORTBP2, KIAA1758, Orf4
Description	Cortactin binding protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q31.31
Chromosome location (bp)	117710651 - 117874139
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000077063 (version 83.38)
Entrez gene	83992
UniProt	Q8WZ74 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WZ74
Antibodypedia	CTTNBP2 antibodies

PROTEIN BROWSER

CTTNBP2-001	CTTNBP2-002	CTTNBP2-004	CTTNBP2-006	CTTNBP2-007	CTTNBP2-009	CTTNBP2-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTTNBP2-001 ENSP00000160373 ENST00000160373	Q8WZ74 [Direct mapping] Cortactin-binding protein 2 Q20BG9 [Target identity:100%; Query identity:100%] CTTNBP2; Cortactin binding protein 2; Cortactin binding protein 2, isoform CRA_b Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005938 [cell cortex] GO:0007420 [brain development] GO:0008021 [synaptic vesicle] GO:0017124 [SH3 domain binding] GO:0043197 [dendritic spine] Show all	1663 aa 181.1 kDa	No	0
CTTNBP2-002 ENSP00000396014 ENST00000434890	C9JFC9 [Direct mapping] Cortactin-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		161 aa 18.6 kDa	No	0
CTTNBP2-004 ENSP00000406142 ENST00000416239	H7C2I0 [Direct mapping] Cortactin-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		120 aa 13.4 kDa	No	0
CTTNBP2-006 ENSP00000405831 ENST00000454375	C9J720 [Direct mapping] Cortactin-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		136 aa 15.7 kDa	No	0
CTTNBP2-007 ENSP00000393373 ENST00000412853	C9JVQ6 [Direct mapping] Cortactin-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		95 aa 10.9 kDa	No	0
CTTNBP2-009 ENSP00000395925 ENST00000435233	H7C0N3 [Direct mapping] Cortactin-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		193 aa 21.4 kDa	No	0
CTTNBP2-011 ENSP00000389576 ENST00000446636	H0Y448 [Direct mapping] Cortactin-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1151 aa 125.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.