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RARB

GENERAL INFORMATION

Gene name

 RARB

Gene description

 Retinoic acid receptor, beta

Protein class

 Cancer-related genes
Disease related genes
FDA approved drug targets
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear and cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA004174 , CAB002617
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Thyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RARB (HGNC Symbol)

Synonyms

 HAP, NR1B2, RRB2

Description

 Retinoic acid receptor, beta (HGNC Symbol)

Entrez gene summary

 This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]

Chromosome

 3

Cytoband

 p24.2

Chromosome location (bp)

 25174332 - 25597932

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000077092 (version 83.38)

Entrez gene

 5915

UniProt

 P10826 (UniProt - Evidence at protein level)

neXtProt

 NX_P10826

Antibodypedia

 RARB antibodies

PROTEIN BROWSER
RARB-001
RARB-002
RARB-004
RARB-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RARB-001
ENSP00000332296
ENST00000330688
P10826 [Direct mapping]
Retinoic acid receptor beta
F1D8S6 [Target identity:100%; Query identity:100%]
Retinoic acid receptor beta variant 1; Retinoic acid receptor, beta, isoform CRA_a
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Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001657 [ureteric bud development]
GO:0002068 [glandular epithelial cell development]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003406 [retinal pigment epithelium development]
GO:0003417 [growth plate cartilage development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003708 [retinoic acid receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008144 [drug binding]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0021756 [striatum development]
GO:0022008 [neurogenesis]
GO:0031641 [regulation of myelination]
GO:0032331 [negative regulation of chondrocyte differentiation]
GO:0032403 [protein complex binding]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0035264 [multicellular organism growth]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043068 [positive regulation of programmed cell death]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046965 [retinoid X receptor binding]
GO:0048048 [embryonic eye morphogenesis]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0048566 [embryonic digestive tract development]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060041 [retina development in camera-type eye]
GO:0060348 [bone development]
GO:0061037 [negative regulation of cartilage development]
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 448 aa
50.3 kDa 		No 0
RARB-002
ENSP00000398840
ENST00000437042
P10826 [Direct mapping]
Retinoic acid receptor beta
Q5QHG3 [Target identity:100%; Query identity:100%]
Retinoic acid receptor beta 5; Retinoic acid receptor beta variant 2; Retinoic acid receptor, beta, isoform CRA_b
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003708 [retinoic acid receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0048566 [embryonic digestive tract development]
Show all
 336 aa
37.9 kDa 		No 0
RARB-004
ENSP00000391391
ENST00000458646
P10826 [Direct mapping]
Retinoic acid receptor beta
Q5QHG3 [Target identity:100%; Query identity:100%]
Retinoic acid receptor beta 5; Retinoic acid receptor beta variant 2; Retinoic acid receptor, beta, isoform CRA_b
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003708 [retinoic acid receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0048566 [embryonic digestive tract development]
Show all
 336 aa
37.9 kDa 		No 0
RARB-005
ENSP00000373282
ENST00000383772
D6RBI3 [Direct mapping]
Retinoic acid receptor beta
Show all
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003708 [retinoic acid receptor activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0048384 [retinoic acid receptor signaling pathway]
Show all
 402 aa
45.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.