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USP33

GENERAL INFORMATION

Gene name

 USP33

Gene description

 Ubiquitin specific peptidase 33

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA005719
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 USP33 (HGNC Symbol)

Synonyms

 KIAA1097, VDU1

Description

 Ubiquitin specific peptidase 33 (HGNC Symbol)

Entrez gene summary

 This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 adrenergic receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

Chromosome

 1

Cytoband

 p31.1

Chromosome location (bp)

 77695987 - 77759852

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000077254 (version 83.38)

Entrez gene

 23032

UniProt

 Q8TEY7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TEY7

Antibodypedia

 USP33 antibodies

PROTEIN BROWSER
USP33-001
USP33-002
USP33-003
USP33-004
USP33-010
USP33-012
USP33-013
USP33-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
USP33-001
ENSP00000359830
ENST00000370794
Q8TEY7 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 33
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005776 [autophagosome]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006897 [endocytosis]
GO:0007411 [axon guidance]
GO:0008270 [zinc ion binding]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009267 [cellular response to starvation]
GO:0010506 [regulation of autophagy]
GO:0016477 [cell migration]
GO:0016579 [protein deubiquitination]
GO:0017160 [Ral GTPase binding]
GO:0030891 [VCB complex]
GO:0032091 [negative regulation of protein binding]
GO:0032092 [positive regulation of protein binding]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050821 [protein stabilization]
GO:0051298 [centrosome duplication]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
Show all
 911 aa
103.3 kDa 		No 0
USP33-002
ENSP00000359829
ENST00000370793
Q8TEY7 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 33
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005776 [autophagosome]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006897 [endocytosis]
GO:0007411 [axon guidance]
GO:0008270 [zinc ion binding]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009267 [cellular response to starvation]
GO:0010506 [regulation of autophagy]
GO:0016477 [cell migration]
GO:0016579 [protein deubiquitination]
GO:0017160 [Ral GTPase binding]
GO:0030891 [VCB complex]
GO:0032091 [negative regulation of protein binding]
GO:0032092 [positive regulation of protein binding]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044297 [cell body]
GO:0045111 [intermediate filament cytoskeleton]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050821 [protein stabilization]
GO:0051298 [centrosome duplication]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
Show all
 942 aa
106.7 kDa 		No 0
USP33-003
ENSP00000359828
ENST00000370792
Q8TEY7 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 33
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005776 [autophagosome]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006897 [endocytosis]
GO:0007411 [axon guidance]
GO:0008270 [zinc ion binding]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009267 [cellular response to starvation]
GO:0010506 [regulation of autophagy]
GO:0016477 [cell migration]
GO:0016579 [protein deubiquitination]
GO:0017160 [Ral GTPase binding]
GO:0030891 [VCB complex]
GO:0032091 [negative regulation of protein binding]
GO:0032092 [positive regulation of protein binding]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050821 [protein stabilization]
GO:0051298 [centrosome duplication]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
Show all
 828 aa
94 kDa 		No 0
USP33-004
ENSP00000432392
ENST00000481579
H0YCV3 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 33
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 456 aa
51.7 kDa 		No 0
USP33-010
ENSP00000434441
ENST00000524536
E9PQP0 [Direct mapping]
Ubiquitinyl hydrolase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0008270 [zinc ion binding]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 202 aa
22.6 kDa 		No 0
USP33-012
ENSP00000436441
ENST00000524778
E9PP47 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 33
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 73 aa
8.2 kDa 		No 0
USP33-013
ENSP00000433283
ENST00000530709
E9PLK7 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 33
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 111 aa
12.4 kDa 		No 0
USP33-201
ENSP00000350009
ENST00000357428
Q8TEY7 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 33
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005776 [autophagosome]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006897 [endocytosis]
GO:0007411 [axon guidance]
GO:0008270 [zinc ion binding]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009267 [cellular response to starvation]
GO:0010506 [regulation of autophagy]
GO:0016477 [cell migration]
GO:0016579 [protein deubiquitination]
GO:0017160 [Ral GTPase binding]
GO:0030891 [VCB complex]
GO:0032091 [negative regulation of protein binding]
GO:0032092 [positive regulation of protein binding]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050821 [protein stabilization]
GO:0051298 [centrosome duplication]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
Show all
 942 aa
106.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.