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POLD3

GENERAL INFORMATION

Gene name

 POLD3

Gene description

 Polymerase (DNA-directed), delta 3, accessory subunit

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA058846
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 POLD3 (HGNC Symbol)

Synonyms

 KIAA0039, P66, P68, PPP1R128

Description

 Polymerase (DNA-directed), delta 3, accessory subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]

Chromosome

 11

Cytoband

 q13.4

Chromosome location (bp)

 74493851 - 74669117

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000077514 (version 83.38)

Entrez gene

 10714

UniProt

 Q15054 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15054

Antibodypedia

 POLD3 antibodies

PROTEIN BROWSER
POLD3-001
POLD3-002
POLD3-003
POLD3-005
POLD3-006
POLD3-007
POLD3-009
POLD3-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLD3-001
ENSP00000263681
ENST00000263681
Q15054 [Direct mapping]
DNA polymerase delta subunit 3
A0A024R5M8 [Target identity:100%; Query identity:100%]
Polymerase (DNA-directed), delta 3, accessory subunit, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0000731 [DNA synthesis involved in DNA repair]
GO:0003887 [DNA-directed DNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006260 [DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006298 [mismatch repair]
GO:0019985 [translesion synthesis]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0043625 [delta DNA polymerase complex]
GO:0070911 [global genome nucleotide-excision repair]
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 466 aa
51.4 kDa 		No 0
POLD3-002
ENSP00000432951
ENST00000527458
Q15054 [Direct mapping]
DNA polymerase delta subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0000731 [DNA synthesis involved in DNA repair]
GO:0003887 [DNA-directed DNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006260 [DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006298 [mismatch repair]
GO:0019985 [translesion synthesis]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0043625 [delta DNA polymerase complex]
GO:0070911 [global genome nucleotide-excision repair]
Show all
 427 aa
46.8 kDa 		No 0
POLD3-003
ENSP00000436018
ENST00000532497
Q15054 [Direct mapping]
DNA polymerase delta subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0000731 [DNA synthesis involved in DNA repair]
GO:0003887 [DNA-directed DNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006260 [DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006298 [mismatch repair]
GO:0019985 [translesion synthesis]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0043625 [delta DNA polymerase complex]
GO:0070911 [global genome nucleotide-excision repair]
Show all
 360 aa
39.3 kDa 		No 0
POLD3-005
ENSP00000432233
ENST00000530511
E9PRK3 [Direct mapping]
DNA polymerase delta subunit 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
Show all
 169 aa
18.4 kDa 		No 0
POLD3-006
ENSP00000437231
ENST00000531615
E9PNC0 [Direct mapping]
DNA polymerase delta subunit 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
Show all
 138 aa
15.2 kDa 		No 0
POLD3-007
ENSP00000432969
ENST00000524752
H0YD46 [Direct mapping]
DNA polymerase delta subunit 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
Show all
 149 aa
16.7 kDa 		No 0
POLD3-009
ENSP00000436781
ENST00000532954
H0YEX7 [Direct mapping]
DNA polymerase delta subunit 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
Show all
 89 aa
10 kDa 		No 0
POLD3-010
ENSP00000431239
ENST00000528481
E9PM91 [Direct mapping]
DNA polymerase delta subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
Show all
 111 aa
12.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.