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CAPZB

CANCER ATLAS

Gene description

 Capping protein (actin filament) muscle Z-line, beta

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA031531

GENE INFORMATION

Gene name

 CAPZB

Synonyms

Description

 Capping protein (actin filament) muscle Z-line, beta (HGNC Symbol)

Entrez gene summary

 This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]

Chromosome

 1

Cytoband

 p36.13

Chromosome location (bp)

 19338776 - 19485539

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000077549 (version 83.38)

Entrez gene

 832

UniProt

 P47756 (UniProt - Evidence at protein level)

neXtProt

 NX_P47756

Antibodypedia

 CAPZB antibodies

PROTEIN BROWSER
CAPZB-001
CAPZB-002
CAPZB-003
CAPZB-008
CAPZB-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CAPZB-001
ENSP00000364286
ENST00000375144
B1AK87 [Direct mapping]
Capping protein (Actin filament) muscle Z-line, beta, isoform CRA_a; F-actin-capping protein subunit beta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0003779 [actin binding]
GO:0005737 [cytoplasm]
GO:0005884 [actin filament]
GO:0008290 [F-actin capping protein complex]
GO:0010591 [regulation of lamellipodium assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051490 [negative regulation of filopodium assembly]
Show all
 260 aa
29.3 kDa 		No 0
CAPZB-002
ENSP00000264203
ENST00000264203
B1AK85 [Direct mapping]
F-actin-capping protein subunit beta; cDNA FLJ43095 fis, clone CORDB2000541, highly similar to F-actin capping protein subunit beta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0003779 [actin binding]
GO:0005737 [cytoplasm]
GO:0005884 [actin filament]
GO:0008290 [F-actin capping protein complex]
GO:0010591 [regulation of lamellipodium assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051490 [negative regulation of filopodium assembly]
Show all
 260 aa
29.3 kDa 		No 0
CAPZB-003
ENSP00000364284
ENST00000375142
P47756 [Direct mapping]
F-actin-capping protein subunit beta
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0003779 [actin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0006928 [movement of cell or subcellular component]
GO:0007010 [cytoskeleton organization]
GO:0007596 [blood coagulation]
GO:0008290 [F-actin capping protein complex]
GO:0010591 [regulation of lamellipodium assembly]
GO:0015629 [actin cytoskeleton]
GO:0022604 [regulation of cell morphogenesis]
GO:0030017 [sarcomere]
GO:0030036 [actin cytoskeleton organization]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051490 [negative regulation of filopodium assembly]
GO:0070062 [extracellular exosome]
GO:0071203 [WASH complex]
Show all
 277 aa
31.4 kDa 		No 0
CAPZB-008
ENSP00000401010
ENST00000433834
B1AK88 [Direct mapping]
Capping protein (Actin filament) muscle Z-line, beta, isoform CRA_d; F-actin-capping protein subunit beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0001669 [acrosomal vesicle]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005884 [actin filament]
GO:0005903 [brush border]
GO:0008290 [F-actin capping protein complex]
GO:0010591 [regulation of lamellipodium assembly]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030030 [cell projection organization]
GO:0030032 [lamellipodium assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030863 [cortical cytoskeleton]
GO:0031115 [negative regulation of microtubule polymerization]
GO:0031175 [neuron projection development]
GO:0048487 [beta-tubulin binding]
GO:0048747 [muscle fiber development]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051490 [negative regulation of filopodium assembly]
GO:0090036 [regulation of protein kinase C signaling]
Show all
 301 aa
33.8 kDa 		No 0
CAPZB-010
ENSP00000264202
ENST00000264202
P47756 [Direct mapping]
F-actin-capping protein subunit beta
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0003779 [actin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0006928 [movement of cell or subcellular component]
GO:0007010 [cytoskeleton organization]
GO:0007596 [blood coagulation]
GO:0008290 [F-actin capping protein complex]
GO:0010591 [regulation of lamellipodium assembly]
GO:0015629 [actin cytoskeleton]
GO:0022604 [regulation of cell morphogenesis]
GO:0030017 [sarcomere]
GO:0030036 [actin cytoskeleton organization]
GO:0051015 [actin filament binding]
GO:0051016 [barbed-end actin filament capping]
GO:0051490 [negative regulation of filopodium assembly]
GO:0070062 [extracellular exosome]
GO:0071203 [WASH complex]
Show all
 272 aa
30.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.